Patients with toxic epidermal necrolysis in intensive care unit of Regional Burn Center [Bölge Yanik Merkezi· yogun bakim üni·tesi·'nde toksi·k epi·dermal nekroli·zi·s'li· hastalar]
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Objective: Toxic epidermal necrolysis (TEN) is a potentially life-threatening rare disorder, resulting in possible sepsis and death. The aim of this study is to determine the mortality rate, associated comorbidities, the clinical and epidemiological characteristics of 12 TEN patients hospitalized in our burn unit. Method: Twelve patients diagnosed with TEN and admitted to the burn intensive care unit were included in the study. Age, gender, medication, percentage and depth of skin burn damage, APACHE II scores, surgical interventions, hospitalization time, the duration of mechanical ventilation, complications, mortality and morbidity rates of patients were documented in a retrospective manner. The Scorten Scale was utilized to determine the mortality rate of the patients. Results: Mean age was 35±5.7 years. The ratio of males to females was 5:7 and the average APACHE II score was 15.4±3.2. Epidermal detachment was greater than 75% of the body surface area with a mean hospitalization time of 17±1.2 days. One patient had a history of paracetamol and etodolac, 3 had phenytoin medication. TEN symptoms were seen as a result of anti-tuberculosis treatment in another patient and appeared in four patients after treatment with sultamicilin. Other patients had an unknown etiology. Mean duration of mechanical ventilation support was 3.2±0.7 days. The mortality rate was 16.6% (2/12). Conclusion: Due to the high risk of mortality, patients with TEN may require different approaches and management strategies. We concluded that early identification and interception of the responsible drug and the provision of a specialized supportive care in a burn unit may reduce the mortality rate for toxic epidermal necrolysis.