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dc.contributor.authorEkici, Sinan
dc.contributor.authorEkici, A. Isin Dogan
dc.contributor.authorOzturk, Guler
dc.contributor.authorAksungar, Fehime Benli
dc.contributor.authorSinanoglu, Orhun
dc.contributor.authorTuran, Guven
dc.contributor.authorLuleci, Nurettin
dc.descriptionWOS: 000309518700042en_US
dc.descriptionPubMed ID: 22950989en_US
dc.description.abstractOBJECTIVE To compare the efficacy of ozone with melatonin, shown as the most powerful antioxidant in attenuation of testicular ischemia/reperfusion injury, in an experimental rat model of testicular torsion/detorsion. METHODS Twenty-four male Wistar rats were divided into 4 groups: sham-operated, torsion/detorsion, torsion/detorsion plus melatonin, and torsion/detorsion plus ozone. Melatonin (10 mg/kg) and ozone (4 mg/kg) were intraperitoneally injected daily beginning 15 minutes before detorsion for the following 7 days. At the seventh day, blood and tissue samples were obtained. Johnsen score, malondialdehyde, inhibin B, glutathione plasma total sulfhydryl group (RSH) levels, and total nitric oxide were studied. RESULTS Torsion/detorsion caused increase in tissue malondialdehyde and total nitric oxide along with a decrease in Johnsen score, tissue and plasma inhibin B, RSH, and glutathione levels. Melatonin prevented the rise in malondialdehyde and total nitric oxide levels and improved Johnsen score, tissue and plasma inhibin B, and tissue glutathione levels, along with a decrease in plasma RSH level. Ozone showed similar results except for the total nitric oxide level. Concomitantly, in contralateral testis, melatonin and ozone induced similar changes for Johnsen score, malondialdehyde, and inhibin B (not significant) and in glutathione (significant). Melatonin decreased the total nitric oxide level in both testes and ozone increased the same parameter. CONCLUSION On different pathways, ozone was comparable with melatonin in the amelioration of ischemia/reperfusion injury. Protective effects of ozone were associated with nitrous oxide. The potential for ozone as a treatment for torsion/detorsion therefore deserves to be further elucidated. UROLOGY 80: 899-906, 2012. (C) 2012 Elsevier Inc.en_US
dc.description.sponsorshipEthical Committee on Animal Care and Use of Maltepe University [M.U.ET.-2011.03]en_US
dc.description.sponsorshipThis research was approved by the Ethical Committee on Animal Care and Use of Maltepe University. (M.U.ET.-2011.03).en_US
dc.titleComparison of Melatonin and Ozone in the Prevention of Reperfusion Injury Following Unilateral Testicular Torsion in Ratsen_US
dc.contributor.department[Ekici, Sinan] Maltepe Univ, Sch Med, Dept Urol, TR-34843 Istanbul, Turkey; Yeditepe Univ, Sch Med, Dept Pathol, Istanbul, Turkey; Maltepe Univ, Sch Med, Dept Physiol, TR-34843 Istanbul, Turkey; Maltepe Univ, Sch Med, Dept Biochem, TR-34843 Istanbul, Turkey; Maltepe Univ, Sch Med, Dept Anesthesiol, TR-34843 Istanbul, Turkeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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