Do deferoxamine, ticlopidin or trimetazidine prevent sevoflurane nephrotoxicity? An electron microscopic study
CitationKaramanlıoğlu, B. ve Aktaş, R. G. (2003). Do deferoxamine, ticlopidin or trimetazidine prevent sevoflurane nephrotoxicity? An electron microscopic study. Microscopy and Microanalysis, Cambridge University Press. 9, s. 1428-1429.
Sevoflurane is a common anesthetic drug. Several biochemical, pharmacologic and physiologic studies have showed nephrotoxicity of Sevoflurane[1,2,3]. Histopathologic studies reported tubular damage and tubular cellular hyperplasia after the administration of Sevoflurane. Deferoxamine(DFO) is known to protect against myoglobinuric acute renal failure. It has been suggested that Ticlopidine(TIC) does not prevent nephropathies but has beneficial effects. Fang et al. showed that TIC inhibited mesangial cell proliferation and collagen synthesis. There is another study reporting that TIC induces acute interstitial nephrite and cause an increase of the number of lymphocytes and eosinophil leucocytes in interstitial tissue. Trimetazidine(TMZ) has anti-ischemic effects and protects tissue damage in kidney[5, 9, 10, 11]. These studies lead us to investigate if DFO, TIC or TMZ can prevent the nephrotoxicity of Sevoflurane at morphologic level.
SourceMicroscopy and Microanalysis
- Makale Koleksiyonu 
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