Histological study of the healing of traumatic tympanic membrane perforation after Vivosorb and Epifilm application

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dc.authorid0000-0001-7914-2201en_US
dc.contributor.authorYılmaz, Mahmut Sinan
dc.contributor.authorŞahin, Elvan
dc.contributor.authorKaymaz, Recep
dc.contributor.authorAltunkaynak, Berrin Zuhal
dc.contributor.authorAkidil, Ayşe Öznur
dc.contributor.authorYanar, Sevinç
dc.contributor.authorDemir, Deniz
dc.contributor.authorGüven, Mehmet
dc.contributor.authorDemir, Deniz
dc.date.accessioned2024-07-12T21:00:31Z
dc.date.available2024-07-12T21:00:31Z
dc.date.issued2019en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground: Untreated traumatic tympanic membrane perforations (TMPs) may lead to permanent perforations and hearing loss. There are many materials that have been previously used for repairing the TMPs. Aims and Objectives: The purpose of this study is to evaluate the clinical and histological effects of Vivosorb (Vv) and Epifilm on healing of TMPs in a rat model. Material and Methods: The posterior-inferior quadrant of the tympanic membranes (TMs) in right ears of 14 rats was perforated using a 20-g needle and then the animals were randomly divided into 2 equal groups (n = 7). The perforated right TMs were treated with either Vv (Vv group) or Epifilm (Ep group). The left TMs of 7 rats were perforated in same way and allowed to close spontaneously without any topical material applications (spontaneous closure group as sham control, SC). The left tympanic membranes of the other 7 rats were not perforated and used as normal controls (NC group). On postoperative 15th day, tympanic bullas were extracted from killed rats and examined morphometrically and histopathologically. Results: Perforation closure rate was 85.7% (6/7) in both Vv and SC groups. Perforations of Ep group closed in 7/7 (100%) ears. The thicknesses of the perforated membranes were increased in SC and especially Vv groups. Also, connective tissue fibrosis, blood clots, and epithelial degenerations were detected in SC and Vv groups. The mean fibroblastic reaction scores of Vv, Ep, and SC groups were 2.14(+), 0.57(+), and 1.71(+) respectively, on comparison with NC group. The mean neovascularization score was 1.42(+) in Vv group, 0.14(+) in Ep group, and 0.57(+) in SC group. Conclusion and Significance: Vivosorb and especially Epifilm can improve the healing process in traumatic TMPs and additionally, Epifilm might be more preferred for the treatment of TMPs because of causing lesser fibrosis.en_US
dc.identifier.citationYılmaz, M.S., Şahin, E., Kaymaz, R., Altunkaynak, B.Z., Akidil, A.Ö., Yanar, S., Demir, D. ve Güven, M. (2019). Histological study of the healing of traumatic tympanic membrane perforation after Vivosorb and Epifilm application. Ear, Nose & Throat Journal, SAGE Journals. 100(2), s. 90-96.en_US
dc.identifier.endpage96en_US
dc.identifier.issn1942-7522
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage90en_US
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/0145561319854320?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3390
dc.identifier.volume100en_US
dc.institutionauthorDemir, Deniz
dc.language.isoenen_US
dc.publisherSAGE Journalsen_US
dc.relation.ispartofEar, Nose & Throat Journalen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00669
dc.subjectepifilmen_US
dc.subjecthistologyen_US
dc.subjectotologic surgeryen_US
dc.subjecttympanic membrane perforationen_US
dc.subjectvivosorben_US
dc.titleHistological study of the healing of traumatic tympanic membrane perforation after Vivosorb and Epifilm applicationen_US
dc.typeArticle
dspace.entity.typePublication

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