Do deferoxamine, ticlopidine or trimetazidine prevent sevoflurane nephrotoxicity? An electron microscopic study

dc.authorid0000-0002-4474-7371en_US
dc.contributor.authorKaramanlıoğlu, B.
dc.date.accessioned2024-07-12T21:10:13Z
dc.date.available2024-07-12T21:10:13Z
dc.date.issued2003en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractSevoflurane is a common anesthetic drug. Several biochemical, pharmacologic and physiologic studies have showed nephrotoxicity of Sevoflurane[1,2,3]. Histopathologic studies reported tubular damage and tubular cellular hyperplasia after the administration of Sevoflurane[4]. Deferoxamine(DFO) is known to protect against myoglobinuric acute renal failure[5]. It has been suggested that Ticlopidine(TIC) does not prevent nephropathies but has beneficial effects[6]. Fang et al. showed that TIC inhibited mesangial cell proliferation and collagen synthesis[7]. There is another study reporting that TIC induces acute interstitial nephrite and cause an increase of the number of lymphocytes and eosinophil leucocytes in interstitial tissue[8]. Trimetazidine(TMZ) has anti-ischemic effects and protects tissue damage in kidney[5, 9, 10, 11]. These studies lead us to investigate if DFO, TIC or TMZ can prevent the nephrotoxicity of Sevoflurane at morphologic level.en_US
dc.identifier.citationKaramanlıoğlu, B. ve Aktaş, R. G. (2003). Do deferoxamine, ticlopidine or trimetazidine prevent sevoflurane nephrotoxicity? An electron microscopic study. Microscopy and Microanalysis, Cambridge University Press. 9(2), s. 1428-1429.en_US
dc.identifier.endpage1429en_US
dc.identifier.issn1435-8115
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1428en_US
dc.identifier.urihttps://www.cambridge.org/core/journals/microscopy-and-microanalysis/article/do-deferoxamine-ticlopidin-or-trimetazidine-prevent-sevoflurane-nephrotoxicity-an-electron-microscopic-study/226E6AEA4E9FD98B471ABE350D92C5D4
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4214
dc.identifier.volume9en_US
dc.institutionauthorAktaş, Ranan Gülhan
dc.language.isoenen_US
dc.publisherCambridge University Pressen_US
dc.relation.ispartofMicroscopy and Microanalysisen_US
dc.relation.isversionof10.1017/S1431927603447144en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY02939
dc.titleDo deferoxamine, ticlopidine or trimetazidine prevent sevoflurane nephrotoxicity? An electron microscopic studyen_US
dc.typeArticle
dspace.entity.typePublication

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