Cetinkaya, M.Erener-Ercan, T.Kalayci-Oral, T.Babayigit, A.Cebeci, B.Semerci, S. Y.Buyukkale, G.2024-07-122024-07-1220170743-83461476-554310.1038/jp.2017.182-s2.0-85015926151https://dx.doi.org/10.1038/jp.2017.18https://hdl.handle.net/20.500.12415/8255OBJECTIVE: The objective of the study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of necrotizing enterocolitis (NEC). STUDY DESIGN: One hundred and forty-five preterm infants. 36 weeks of gestation were enrolled. 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit. RESULTS: Of the 145 enrolled patients, 26 (18%) developed NEC. Maternal/neonatal 25-OHD levels in the NEC group were significantly lower than those of the no-NEC group (P = 0.001 and 0.004, respectively). In univariate logistic regression analysis, both maternal/neonatal vitamin D levels were a significant predictor of NEC (odds ratio (OR): 0.92 and 0.89; P < 0.001 and P < 0.005, respectively). However, multivariate logistic regression analysis revealed that only maternal vitamin D level was a significant predictor of NEC (OR: 0.86, P < 0.0009). CONCLUSION: This is the first study to propose a possible association between maternal/neonatal 25-OHD levels and subsequent development of NEC in preterm infants.eninfo:eu-repo/semantics/closedAccessArticle678628333154Q167337WOS:000402295200013Q2