Öztürk, A.Orhan, B.Kandemir, E. G.Yaylacı, M.2024-07-122024-07-122002Türken, O., Öztürk, A., Orhan, B., Kandemir, E.G. ve Yaylacı, M. (2002). A Case report: large granular cell leukemia/lymphoma. Turkish Journal of Hematology, Turkish Society of Hematology. 19(4), s. 473-476.1308-5263https://tjh.com.tr/jvi.aspx?pdir=tjh&plng=eng&un=TJH-64946https://hdl.handle.net/20.500.12415/4425We presented a 64-year-old male patient with T-large granular cell leukemia/lymphoma with an agressive clinical course. Large granular lymphocytes were noted on peripheral blood smear. The phenotyping of the cells was typical T-cell lineage [CD2 (+), CD3 (+), CD5 (+)]. Clonal rearrangement of the T-cell receptor gene (TCR) was demonstrated by DNA hybridization technique. Large granular cell leukemia/lymphoma is a distinct entity with spesific clinicobiological aspects. The clinical spectrum is wide and immunophenotyping and genotyping studies need to make a diagnosis.enCC0 1.0 Universalinfo:eu-repo/semantics/openAccessLeukemiaLarge granularArticle4764Q347319