Bilgi, OğuzKaragöz, BülentKandemir, E. GökhanÖztürk, AhmetGümüş, MahmutYaylacı, Mustafa2024-07-122024-07-122008Bilgi, O., Karagoz, B., Turken, O., Kandemir, E. G., Ozturk, A., Gumus, M. ve Yaylaci, M. (2008). Peripheral blood gamma-delta T cells in advanced-stage cancer patients. Advances in therapy, 25(3), 218–224. https://doi.org/10.1007/s12325-008-0032-z0741-238Xhttps://link.springer.com/article/10.1007/s12325-008-0032-zhttps://hdl.handle.net/20.500.12415/3489Gamma-delta T (?? T) cells form a subgroup which has been reported to play a role in both natural and acquired immunity. Their levels have been found to increase in some tumour tissues. The aim of this study was to investigate the ratio of ?? T cells to all T cells in the peripheral blood of advanced-stage cancer patients; the level of ?? T cells expressing the V?2-T-cell receptor (TCR) chain; NKG2D receptor expression; and apoptotic (Annexin-V) ?? T-cell levels. Twenty patients with advanced-stage cancer and 13 healthy controls were included. No statistical differences were found between control and patient groups in terms of the ?? T/total T-cell ratio (P=0.53), the V?2-TCR expressing ?? T-cell ratio (P=0.19) or the Annexin-V ratio (P=0.48). However, NKG2D expression in ?? T cells was significantly different between the control and patient groups (P=0.014). In summary it was shown that the levels of NKG2D receptors, which are responsible for the cytolytic effect of ?? T cells, were lower in cancer patients than in healthy adults. However, no significant differences were observed in the other parameters studied between groups.enCC0 1.0 Universalinfo:eu-repo/semantics/openAccessgamma-delta cellimmunityT cellArticle2243Q121825