Karagöz, BülentAkyol Erikçi, AlevKarabudak, ÖzlemBilgi, OğuzSayan, ÖzkanKandemir, E. GökhanÖztürk, Ahmet2024-07-122024-07-122005Karagöz, B., Akyol Erikçi, A., Karabudak, Ö., Bilgi, O., Sayan, Ö., Türken, O., Kandemir, E. G. ve Öztürk, A. (2005). The diagnosis of non-hodgkin’s lymphoma in epidermodysplasia verruciformis patient. XXX th World Congress of the International Society of Hematology, Turkish Society of Hematology. 22(3), s. 263.1308-5263https://jag.journalagent.com/tjh/pdfs/TJH_22_SUP_3_251_300.pdfhttps://hdl.handle.net/20.500.12415/4588Epidermodysplasia verruciformis (EV) is a rare, multifactorial disorder. This disease contains genetic and immunologic components and accompanies infection with some specific Human Papilloma Virus (HPV) types. The patients may develop multiple in situ and/or invasive squamous cell carcinomas. The most of the patients have impaired cell-mediated immunity. Although EV accompanies frequently skin cancer and extracutanous squamous cell carcinoma, the association between EV and other cancers is not described. In this report, a case of EV with primary mediastinal large B cell lymphoma is presented. A 20-year-old man was seen in our outpatient clinic. He had red-brown macular lesions in sun exposed areas as face and neck for five years duration. EV was diagnosed by histopathologic examination of skin biopsy. One month later, he started to cough. The histological diagnosis of mediastinal mass measuring 6 cm in diameter was diffuse large Bcell lymphoma. B symptoms were absent. He was diagnosed to have stage IAX disease. R-CHOP chemotherapy (Rituximab plus CHOP) and involved field radiotherapy were administered. We have been following this case for 6 months and complete remission is achieved. EV accompanies infection with specific HPV types and is seen in immunosuppressive patients. Some of EV-specific HPVs, particularly HPV 5 and 8 have oncogenic properties. These may have also lymphogenic effect. Moreover the lymphomas are seen frequently in immunosuppressive patients. We conclude that EV may be a predisposition for lymphoma.enCC0 1.0 Universalinfo:eu-repo/semantics/openAccessConference Object2633Q326322