Demir, DenizKarabay, OğuzGüven, MehmetKayabaşoğlu, GürkanYılmaz, Mahmut SinanDemir, Deniz2024-07-122024-07-122016Demir, D., Karabay, O., Güven, M., Kayabaşoğlu, G. ve Yılmaz, M.S. (2016). Do Staphylococcus aureus superantigens play a role in the pathogenesis of otitis media with effusion in children?. International Journal of Pediatric Otorhinolaryngology, Elsevier. 84, s. 71-74.1872-8464https://www.sciencedirect.com/science/article/pii/S0165587616000872https://hdl.handle.net/20.500.12415/3402Objectives Staphylococcal enterotoxins (SEs), acting as superantigens, have been reported to be involved in the pathogenesis of chronic inflammatory diseases of the upper and lower airway. There has been no previous study investigating the role of SEs in otitis media with effusion (OME). Therefore, this study was designed to analyze middle ear aspirates from children with and without OME for the presence of SEs. Methods Middle ear aspirates were obtained from 24 patients and 24 controls. All samples were processed for bacterial culture and detection of five staphylococcal SEs (SEA, SEB, SEC and SED) and toxic shock syndrome toxin-1 using the Rapid Latex Agglutination Test. Results In bacterial culture assays, six samples (25%) of the study group and five samples (20.8%) of the control group showed bacterial growth. At least one SE was demonstrated in 6 of 24 patients and in 3 of 24 controls. There was no statistically significant difference between the two groups with respect to the presence of SEs. Conclusion Although there is evidence that SEs have a potential role in the pathogenesis of chronic inflammatory diseases, there is no evidence that the inflammation process is initiated by SEs in patients with OME.eninfo:eu-repo/semantics/openAccessBacteriaBiofilmOtitis media with effusionMyringotomyEnterotoxinArticle74Q27184