Atasayan, KemalYoldemir, Tevfik2024-07-122024-07-122020Atasayan, K. ve Yoldemir, T. (2020). The effect of PCOS status on atherosclerosis markers and cardiovascular disease risk factors in young women with vitamin D deficiency. Gynecological Endocrinology, Taylor & Francis.1473-076610.1080/09513590.2020.18264282-s2.0-85091877538https://www.tandfonline.com/doi/full/10.1080/09513590.2020.1826428https://doi.prg/10.1080/09513590.2020.1826428https://hdl.handle.net/20.500.12415/7594Objective To investigate whether polycystic ovary syndrome (PCOS) had further deteriorating influence on endothelial function or cardiometabolic parameters in women with vitamin D deficiency during reproductive age. Study design The study group was composed of women with PCOS and vitamin D deficiency and insufficiency between the ages of 18 and 35 years. Age and body mass index (BMI)-matched women were chosen as controls. Serum 25(OH) Vit D levels below 20 ng/mL were considered as vitamin D deficiency. The cutoff level of vitamin D insufficiency was suggested at 30 ng/mL. Serum FSH, LH, estradiol, testosterone, DHEA-S, fasting glucose, total cholesterol, HDL, LDL, triglyceride levels were analyzed. Carotid artery intima-media thickness (CIMT) was measured, and the flow-mediated vasodilation (FMD) was calculated. Results CIMT and FMD values in both vitamin D deficiency and insufficiency subgroups showed no significant difference between PCOS and non-PCOS groups. There was a weak negative correlation between BMI, waist/hip ratio, CRP, and 25(OH) Vitamin D. Conclusion PCOS is a heterogeneous disease with different combinations of the diagnostic components. Vitamin D is an important variable for a healthy cardiovascular system. We did not find any difference in early atherosclerotic markers and cardiometabolic features between PCOS and non-PCOS group with Vitamin D deficiency.eninfo:eu-repo/semantics/openAccessPCOSvitamin D deficiencyvitamin D insufficiencyCIMTFMDArticle32996333Q2WOS:000573983100001Q3