Ozkokeli, MehmetEs, Mehmet UgurFilizcan, UgurUgurlucan, MuratSasmazel, AhmetTataroglu, Cenk2024-07-122024-07-1220111098-351110.1532/HSF98.201110392-s2.0-80054841184https://dx.doi.org/10.1532/HSF98.20111039https://hdl.handle.net/20.500.12415/8028Background: Surgery for thoracic and thoracoabdominal aortic aneurysms can be complicated by a significant incidence of neurogenic deficits due to spinal cord ischemia. In this study, we investigated whether ischemic preconditioning (IPC) improves neurologic outcome in a rabbit model. Methods: Forty rabbits underwent infrarenal aortic occlusion. The IPC group (n = 20) had 10 minutes of aortic occlusion to induce spinal cord ischemia, 40 minutes of reperfusion, and 30 minutes of ischemia, whereas the control group (n = 20) had only 30 minutes of ischemia. Tarlov scoring (0, paraplegia; 4, normal) was used to evaluate neurologic functions 7 days later, and spinal cord segments (L4-L6) were stained with hematoxylin and eosin for histologic evaluation. Results: Complete paraplegia (grade 0) occurred in 15 (75%) of the 20 control animals, whereas in the IPC group, 13 (65%) of 20 animals were completely normal (grade 4) (P < .05). Conclusion: IPC is beneficial for protecting against neurologic damage after transient aortic occlusion in a rabbit model; however, the protective mechanisms are not clear.eninfo:eu-repo/semantics/closedAccessArticleE321521997656Q3E31714WOS:000296341700010Q4