Kök Kendirlioğlu, BurcuÖzpercin, Pelin UnalanOksuz, Özge YukselSozen, ŞuleCihnioğlu, RefikKalelioğlu, TevfikIlnem, Mehmet Cem2024-07-122024-07-1220200803-94881502-472510.1080/08039488.2019.16734802-s2.0-85074048725https://doi.org/10.1080/08039488.2019.1673480https://hdl.handle.net/20.500.12415/6893Background: Resolvin D1 (RvD1) is a soluble mediator, which is the metabolite of docosahexaenoic acid (DHA), an omega-3 fatty acid. It is thought that RvD1 may contribute to the etiology of bipolar disorder (BD) because of its anti-inflammatory and antidepressant effect. In this study, it was aimed to compare the serum RvD1 levels of patients with BD diagnosed manic-depressive-euthymic episodes with those of healthy subjects. The secondary objective of this study is to investigate the relationship between RvD1 measures and inflammatory markers. Methods: We included 121 male patients with BD type I, 44 in a mania, 35 in depression and 42 in euthymic state, and 41 healthy controls. Serum RvD1 levels and inflammation indicators (CRP, neutrophil, leukocyte, and albumin) were measured. Results: When the RvD1 values of patients were compared, the median (interquartile range) RvD1 value was 11.2 (5.2) for manic patients, 11.2 (6.6) for depressive patients, 9.6 (5.6) for euthymic patients and 8.4 (7.7) for the control group. There were statistically significant differences between the groups in terms of RvD1 values (p?eninfo:eu-repo/semantics/closedAccessResolvin D1Bipolar DisorderInflammationFatty AcidAntiinflammatoryArticle88231575320Q28374WOS:000488410400001Q3