Şahin, BaharSayın, SercanÇelik, Arzu2024-07-122024-07-122014Şahin, B., Sayın, S. ve Çelik, A. (2014). Insulin pathway related salt inducible kinases in fruit fly retina development. Frontiers in Medical Sciences: Diabetes, Cancer and Their Connection / Tıpta Yenilikler: Diyabet, Kanser ve İlişkileri, Maltepe Üniversitesi. s. 89.https://hdl.handle.net/20.500.12415/3356Salt inducible kinases (SIKs) are Ser/Thr kinases members of AMPK-RK family. Upon regulation by glucagon induced PKA signal, SIKs regulate IRS-1, CRTC activity, and in turn CREB. Via the insulin induced Akt, SIKs are known to inhibit CREB and CRTC. Besides the long known role in insulin pathway, SIKs are target of a master tumor suppressor kinase Lkb-1; which is supported by many instances showing SIKs involvement in cancer progression.enCC0 1.0 Universalinfo:eu-repo/semantics/openAccessConference Object9089