Yiğiner, ÖmerCebeci, Bekir SıtkıKardeşoğlu, EjderDemiralp, E.Dinçtürk, Mehmet2024-07-122024-07-122002Cingozbay, B. Y., Yiginer, O., Cebeci, B. S., Kardesoglu, E., Demiralp, E. ve Dincturk, M. (2002). Role of homocysteine for thromboembolic complication in patients with non-valvular atrial fibrilation. Blood coagulation & fibrinolysis, Wolters Kluwer Health. 13(7), s. 609–613.0957-52351473-5733https://journals.lww.com/bloodcoagulation/Fulltext/2002/10000/Role_of_homocysteine_for_thromboembolic.5.aspxhttps://hdl.handle.net/20.500.12415/3587Thromboembolism is the most important complication in patients with atrial fibrilation (AF). Homocysteine is a toxic amino acid that has been recently accepted as a risk factor for atherosclerosis and stroke. The aim of the present study is to show whether there is a relation between hyperhomocysteinemia and thromboembolic complications in patients with non-valvular AF. We admitted 38 patients with non-valvular AF. The patients were divided into two groups: group A (n = 20; mean age, 75.7 +/- 10.4 years; three males/17 females), and group B (n = 18; mean age, 68.0 +/- 10.6 years; 11 males/seven females). While group A consisted of the patients with AF and stroke, group B was composed of the patients with AF but without stroke. The patients having sinus rhythm (15 subjects) were used as the reference group to obtain the cut-off value. Homocysteine was measured by the immunoassay method. The means of the homocysteine levels were 12.4 +/- 3.3 micromol/l in group A, 8.3 +/- 2.3 micromol/l in group B and 9.3 +/- 1.8 micromol/l in the reference group. The cut-off value was 10.6 micromol/l. Group A had a statistically higher homocysteine level than not only group B, but also the reference group (P < 0.05). While 60% of group A (n = 12) had the elevated homocysteine level, the rate was only 22% for group B (n = 4). In conclusion, hyperhomocysteinemia may be one of the explanations for the increased rate of thromboembolic complications in older patients with AF.enCC0 1.0 Universalinfo:eu-repo/semantics/openAccesshomocysteinethromboembolic complicationsatrial fibrilationArticle6137Q360913