Sitar, Mustafa ErinçRezaei, Nima2024-07-122024-07-122022Sitar, M.E. (2022). Biological aging and autoimmunity. Rezaei, N. (Ed.). Translational Autoimmunity içinde (ss.193-203.) San Diego: Elsevier.9.78032E+1210.1016/B978-0-12-824390-9.00016-52-s2.0-85129426231https://www.sciencedirect.com/science/article/pii/B9780128243909000165https://doi.prg/10.1016/B978-0-12-824390-9.00016-5https://hdl.handle.net/20.500.12415/4565All of the functional negative changes that occur in the organism during their lifespan are called “aging.” This phenomenon is a problem as old as the human history. Academicians and authorities of the societies tried to solve the problem on behalf of humanity. Although a lot of information has been obtained about it, not all of its biological mechanisms have been explained. During this process, the changes that occur in the body can be considered holistically or separately. Our immune system, both as a single system and together with other systems like neuroendocrine system, is either directly affected by aging or directly affects aging. Many changes occur, such as elevation of clonal T-cell subsets, postpuberty thymus involution, decline of the ability to differentiate between self and nonself, alteration of the cytokine profile with a tendency to proinflammatory direction, and change in the expression of cell surface receptors. Changes that occur in human immune system, which is also called immunocenescence, are directly associated with the increased risk of autoimmune diseases and malignancies. The procedures that can be done to ensure healthy aging, prevent autoimmune diseases, and decrease the cancer risk and prolong longevity are hidden in these mechanisms.eninfo:eu-repo/semantics/openAccessAdaptive ImmunityAgingAutoimmune diseasesInflammagingImmunosenescenceInnate immunityBook Part2031932