Issin, GizemKucukodaci, ZaferYılmaz, IsmailErkul, EvrenTural, ErsinDemirel, DilaverGüngör, Atila2024-07-122024-07-1220211018-56151309-573010.5146/tjpath.2021.015282-s2.0-85105724171https://doi.org/10.5146/tjpath.2021.01528https://search.trdizin.gov.tr/yayin/detay/523077https://hdl.handle.net/20.500.12415/6907Objective: Although squamous cell carcinomas (SCCs) originating from different anatomic localizations display a similar histological appearance under light microscopy, they may differ in terms of epigenetic and genetic features. The aim of this study was to analyze mir-126, mir-182, and mir-486-5p expression levels in head and neck SCCs and lung SCCs, and to identify localization-specific miRNA expression profiles. Material and Method: The expression levels of mir-126, mir-182, and mir-486-5p were analyzed in lung, oral cavity, laryngeal, and hypopharyngeal SCCs in 40 patients, using quantitative real-time polymerase chain reaction. Results: The findings showed that lung, oral cavity, laryngeal, and hypopharyngeal SCCs have distinct mir-126 and mir-486-5p expression profiles. It was also observed that mir-126 and mir-486-5p expression levels were highly specific to the tumor localization. Conclusion: These findings highlighted that SCCs originating from different anatomic localizations have different miRNA expression profiles. miRNA expression analysis can be used to predict the primary localizations of those SCCs.eninfo:eu-repo/semantics/openAccessHead And NeckLungSquamous Cell CarcinomaMir-126Mir-182Mir-486-5pArticle114233973644Q310652307737WOS:000648892700002N/A