Altaner, S.Güven, A.Coşkun, O.Barut, C.Özen, O. A.2024-07-122024-07-122003Aktasş, R.G., Altaner, S., Güven, A., Coşkun, O., Barut, C. ve Özen, O. A.. (2003). Histopathologic examination of the effects of cyclosporin a alone and the combined therapy with prednisolone on lung: an experimental study. Microscopy and Microanalysis, Cambridge University Press. 9(2), s. 1382-1383.1435-8115https://www.cambridge.org/core/journals/microscopy-and-microanalysis/article/histopathologic-examination-of-the-effects-of-cyclosporin-a-alone-and-the-combined-therapy-with-prednisolone-on-lung-an-experimental-study/4D20A8AC32F293180D1A8AE466F5B2D5https://hdl.handle.net/20.500.12415/4216Cyclosporin-A(CsA) is a very potent immunosuppressive agent which is widely used in transplantations and autoimmune diseases. Recent studies suggest an encouraging clinical effect for low-dose, long-term cyclosporin A treatment in different lung diseases[1,2,3,4,5]. Whether administration of CsA might be useful for lowering the dosage of steroids during the treatment of interstitial pneumonia, asthma and lung injuries[6,7,8] is presently a matter of controversy. Several clinical studies reported that CsA might cause pulmonary complications in transplant recipients [9,10]. The aims of this experimental study were: (i) to examine the effects of CsA on lung at morphologic level and to verify the tolerability of long-term, low-dose treatment with this drug; (ii) to analyze if Cremophor-EL(the vehicle in the intravenous form of CyA) is responsible from the changes; (iii) to investigate if combined therapy with Prednisolone has better morphologic results on lung tissue. Forty-eight female Sprague-Dawley rats were divided into four groups: Group I was control. The other three group had daily intraperitoneal injection of 4mg/kg/day CyA for 2,5 months. Group II had oral, Group III had intravenous form of this drug while Group IV had intravenous form of CsA with 1 mg/kg/day prednisolone. Biopsy specimens from lung were embedded in paraffin and the sections were stained with Hematoxylene & Eosin for microscopic examination.enCC0 1.0 Universalinfo:eu-repo/semantics/openAccessArticle13832Q313829