Kurt, PinarEmek-Savas, Derya DurusuBatum, KubraTurp, BilgeGuntekin, BaharKarsidag, SibelYener, Gorsev Gulmen2024-07-122024-07-1220140953-41801875-858410.1155/2014/2689672-s2.0-84898619064https://dx.doi.org/10.1155/2014/268967https://hdl.handle.net/20.500.12415/7810Background. Event-related oscillations (ERO) may provide a useful tool for the identification of cognitive deficits in mild cognitive impairment (MCI) and Alzheimer's disease (AD). In the present study, we investigate peak-to-peak amplitude of auditory eventrelated delta oscillations of MCI subjects. Method. The study included twenty-two consecutive patients with MCI recruited in neurology clinic and 21 age-and education-matched normal elderly controls. A classical auditory oddball paradigm was used in the experiments. EEG was recorded from F-3, F-z, F-4, C-3, C-z, C-4, P-3, P-z, P-4, O-1, O-z, and O-2 locations. The maximum peak-to-peak amplitudes for each subject's averaged delta response (0.5-2.2Hz) weremeasured. Results. The amplitudes between groups differed significantly at the frontal and mid-centroparietal locations. ANOVA on delta responses revealed a significant effect for groups (F-(1.41) = 4.84, P = 0.033), indicating a larger delta response for healthy controls thanMCI subjects. Post hoc comparisons revealed that peak-to-peak delta response was significantly larger for healthy controls than for MCI over electrode sites F-3, F-z, F-4, C-z, C-4, and Pz. Discussion. Event-related delta frequency band seems to be the most affected oscillatory response in cognitive impairment due to AD. Therefore, it deserves to be investigated as a candidate electrophysiological biomarker in further studies.eninfo:eu-repo/semantics/openAccessArticle24825953Q2WOS:000333848200001Q3