Filinte Taylan, GayeAkan, MithatBilgiç, Mehmet İlkerAköz, Tayfun2024-07-122024-07-122011Filinte Taylan, G., Akan, M., Bilgiç, İ., Karaca, M., Aköz, T. (2011). Chondrogenic effect of the perichondrium graft on the internal derangementand osteoarthritis of the temporomandibular joint of the rabbit. Craniomaxillofacial Surgery Journal. 39(5), s. 351-358.1010-5182https://hdl.handle.net/20.500.12415/3632Internal derangement of the temporomandibular joint is usually defined as the disruption of the condyleand disc relationship. In addition to this description the other elements of the joint including thecartilage surface, synovialfluid, the ligaments and the bony surface itself demonstrate varying degrees ofpathology in concordance with the stage of the internal derangement, as well.Thisstudyisdesignedtocreateanosteoarthriticmodelintherabbittemporomandibularjoint.A2 2mmdefectwasperformedon the cartilage surfaceof the both condylesof each animal (n¼30). The osteoarthriticchanges were demonstrated by computerised tomography sections. The right joints of the animals consti-tuted the control group and the left, the study group. At the time of the defect generation, a perichondriumgraft from the animal’s ear was implanted onto the defect in the study group. The control group was left toheal secondarily. The joints of three randomized groups of 10 animals for each were inspected at the 4th,6th,and 8th weeks.Cartilage regeneration and regression of the osteoarthritic changes were demonstrated in the studygroup both in the 6th and 8th week groups. However, the control group showed less cartilage regen-eration and progression of the osteoarthritic changes in all weeks, with progression with time.The perichondrium graft has demonstrated chondrogenic effect on the condyle and this in turnchanged the progression to internal derangement.eninfo:eu-repo/semantics/openAccessInternal derangementTemporomandibular jointPerichondriumArticle3585Q135139