Caner, MuegeBircan, RifatSevinc, DenizBenli, FehimeGuney, A. IlterKurtoglu, Nuri2024-07-122024-07-1220081415-475710.1590/S1415-475720080050000232-s2.0-62549138704https://dx.doi.org/10.1590/S1415-47572008005000023https://hdl.handle.net/20.500.12415/8011Many epidemiological studies have reported an association between hemostatic factors and risk of both coronary and peripheral artery diseases. Using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated the association between coronary artery disease and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) genes. We screened these gene variants in 174 subjects who had undergone coronary angiography - 115 patients with patent coronary artery disease (grade 3 vessel disease, i.e., significant coronary stenosis), and 59 healthy controls with grade 0 vessel disease. The analysis of our data did not show any statistically significant association between coronary artery disease (CAD) and the investigated polymorphisms.eninfo:eu-repo/semantics/openAccessgenetic polymorphismcoronary diseaseMTHFR geneprothrombin geneFactor V geneArticle8384Q383631WOS:000261856700006Q4