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dc.contributor.authorKüçükkaya B.
dc.contributor.authorÖztürk G.
dc.contributor.authorYalçintepe L.
dc.date.accessioned19.07.201910:50:10
dc.date.accessioned2019-07-19T15:47:19Z
dc.date.available19.07.201910:50:10
dc.date.available2019-07-19T15:47:19Z
dc.date.issued2006
dc.identifier.issn0301-1208
dc.identifier.urihttps://hdl.handle.net/20.500.12415/1248
dc.descriptionPubMed ID: 17133771en_US
dc.description.abstractNitric oxide (NO) is endogenous mediator of numerous physiological processes that range from regulation of cardiovascular function and neurotransmission to antipathogenic and tumoricidal responses. This study was designed to investigate the possible role of NO during erythroid differentiation in K562 erythroleukemia cells. The chronic myelogenous leukemia (K562) cell line can be triggered in culture to differentiate along the erythrocytic pathway, in response to a variety of stimulatory agents. In this study, K562 cells were induced to synthesize hemoglobin by hemin. We investigated NOx (nitrate+nitrite) levels in uninduced (control) and hemin-induced K562 cell lysates during erythroid differentiation. Our results showed that NO levels decreased significantly on fourth and sixth day both in hemin-induced and control cells; the decrease was, however, more in hemin-induced group than in control group.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErythroid differentiationen_US
dc.subjectHeminen_US
dc.subjectK562 cell lineen_US
dc.subjectNitric oxideen_US
dc.titleNitric oxide levels during erythroid differentiation in K562 cell lineen_US
dc.typearticleen_US
dc.relation.journalIndian Journal of Biochemistry and Biophysicsen_US
dc.contributor.departmentMaltepe Üniversitesien_US
dc.identifier.volume43en_US
dc.identifier.issue4en_US
dc.identifier.startpage251en_US
dc.identifier.endpage253en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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