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Yayın Automated aortic supravalvular sinus detection in conventional computed tomography image [Bilgisayarli tomografi görüntülerinde otomatik aortik kapaküstü bölgesi tanimlama](2013) Ünay D.; Harmankaya I.; Öksüz I.; Kadipasaoglu K.; Çubuk R.; Çelik L.Valvular diseases are those where one or more of the cardiac valves are affected. Treatment of valvular diseases often involves replacement or restoration of the affected valve(s). In such a surgical procedure, the medical expert performing the procedure can largely benefit from a patient-specific and dynamic valvular model containing information complementary to the 2D/3D static images. To this end, in this study a novel automated supravalvular sinus detection method (to be used as a first step in aortic valve segmentation) on conventional contrast-enhanced ECG-gated multislice CT data and its evaluation on expert annotated 31 real cases are presented. Results demonstrate a highly accurate detection performance with average error rate inferior to 1.12 mm. © 2013 IEEE.Yayın Coexistence of atypical adenomatous hyperplasia and hamartoma of the lung(2010) Midi A.; Çubuk R.; Yener A.N.; Örki A.; Arman B.Atypical adenomatous hyperplasia is considered to be a preliminary lesion for pulmonary adenocarcinoma while lung hamartomas (mesenchymomas) are non-neoplastic, tumor-like malformations. A patient underwent transthoracic fine-needle aspiration biopsy for a pulmonary mass and then lingulectomy following a diagnosis of adenocarcinoma. The surgical specimen was solid and 25 mm in diameter. Microscopic investigation revealed that the mass was a hamartoma with an atypical adenomatous hyperplasia focus at the periphery. We believe that the cells leading the cancer diagnosis had come from the atypical adenomatous hyperplasia focus around the hamartoma. We presented this case as atypical adenomatous hyperplasia contains atypical epithelium and can be diagnosed as a malignancy on fine needle aspiration biopsy and the coexistence of atypical adenomatous hyperplasia and hamartoma has not been reported previously.Yayın Comparison of hounsfield units of the renal papillae in kidney stone formers and non stone formers [Böbrek taşi olan ve olmayanlarda renal papillalardaki hounsfield birimlerinin kiyaslanmasi](Nobelmedicus, 2014) Sinanoğlu O.; Ekici S.; Çakıroğlu B.; Çubuk R.; Aksoy S.H.Objective: To investigate whether renal papillae of patients with nephrolithiasis are more radiodense than that of control patients and to evaluate the predictibility of urolithiasis events using papillary density differences between stone and non stone formers.Material and Method: Hounsfield unit (HU) values of the papillae of 212 patients with unilateral nephrolithiasis and 108 patients in the control group at the level of the upper pole, middle region and lower pole of both kidneys were evaluated.Results: Mean HU density of all papillae of kidneys with stones was higher than that of stone free kidneys in nephrolithiasis patients (27.21±2.83 vs 25.66±2, p=0.000). Mean HU density of renal papillae of stone patients in calyces with stones was significantly higher than that of all papillae in control patients (25,82±1,97 vs 30,25±4,03, p<0,001). Mean HU density of all papillae in stone-free kidneys of nephrolithiasis patients was not significantly different from that of control patients (25.82±1.97 vs 25.66± 2.57, p=0.642). When the values for control and patient groups according to stone laterality was evaluated, the difference was significant only between right upper and right lower calyces for the right nephrolithiasis and the left middle region for the left nephrolithiasis. (26.32±3.30 vs. 27.90±3.92 and 25.10±3.34 vs. 26.95±4.73, p=0.003 and p=0.009 and 25.70±3.67 vs 27.15±3.77 p= 0.001, respectively).Conclusion: Only the kidneys with stones and especially the patients with papillae facing the stones in nephrolithiasis have higher renal papillary HU. This fact implies the impossibility of HU per se in predicting future urolithiasis events and/or patients; opposing to the findings of a few previous studies. © 2014, Nobelmedicus. All rights reserved.Yayın The value of colonoscopic examination in patients with nonspecific abdominal pain [Non-spesifik karin agrisi bulunan hastalarda kolonoskopik incelemenin yeri](2010) Manukyan, Manuk Norayık; Deveci, Uğur; Kebudi A.; Kapakli S.M.; Çubuk R.; Atasoy M.M.; Deveci, UğurPurpose: The aim of this study was to determine the diagnostic value of colonoscopy in patients with nonspecific abdominal pain Patients and Methods: A prospective observational study was performed at the department of general surgery between March 2006 and March 2009. All patients with abdominal pain (n: 2.604) were evaluated carefully. After a detailed anamnesis, physical examination, laboratory and radiological evaluation, the patients with nonspecific abdominal pain were invited for a colonoscopic examination. Results: Colon cancer was detected in three of the patients aged 59, 63 and 68 years old. Other nine had pedunculated polyps with dysplasia in three of them. Neither had pedicle invasion. Millimetric hyperplastic polyps were detected in 16 other patients. A hundred and ninety eight patients had colonic diverticula. Seventeen of the 25 patients with polyps and 127 of the patients with diverticula were over age 50 years. Conclusion: The value of colonoscopic examination is still controversial in patients with nonspecific abdominal pain. Although the detection rate of malignant and pre-malignant lesions are low, the high detection rate of diverticula and the low complication rate due to the procedure are in favour of colonoscopic examination in these patients.