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Yayın Melatonin & zinc for age management(Turkiye Klinikleri, 2009) Öztürk G.Why do we age? Why do some people seem to age faster than others? Aging results from a complex interplay between multiple different mechanisms. Over the years, researchers have put forth several theories of aging. The most widely accepted theories on the mechanism of aging are error theories and program theories. Melatonin is the main neurohormone of the pineal gland. The pineal gland shrinks with age, so melatonin production declines as we age. The pineal gland is directly involved in the aging process. Being a powerful antioxidant, melatonin may act against age-related oxidative damage. Zinc (Zn) is an essential trace element. Zn levels also decrease with age. The pineal gland is involved in Zn metabolism. The effect of melatonin on immune functions is partly attributed to an interaction with Zn. Melatonin and Zn treatment in old mice restored the reduced immunological functions. There is a tight relationship between melatonin and Zn. Melatonin and Zn supplementation may postpone aging. Copyright © 2009 by Türkiye Klinikleri.Yayın Nitric oxide levels during erythroid differentiation in K562 cell line(2006) Küçükkaya B.; Öztürk G.; Yalçintepe L.Nitric oxide (NO) is endogenous mediator of numerous physiological processes that range from regulation of cardiovascular function and neurotransmission to antipathogenic and tumoricidal responses. This study was designed to investigate the possible role of NO during erythroid differentiation in K562 erythroleukemia cells. The chronic myelogenous leukemia (K562) cell line can be triggered in culture to differentiate along the erythrocytic pathway, in response to a variety of stimulatory agents. In this study, K562 cells were induced to synthesize hemoglobin by hemin. We investigated NOx (nitrate+nitrite) levels in uninduced (control) and hemin-induced K562 cell lysates during erythroid differentiation. Our results showed that NO levels decreased significantly on fourth and sixth day both in hemin-induced and control cells; the decrease was, however, more in hemin-induced group than in control group.Yayın Serum levels of nitric oxide end products and interactions with lipoproteins in patients with coronary artery disease(2004) Afrasyap L.; Öztürk G.; Erbaş D.The purpose of this study was to examine whether the serum levels of nitric oxide end products and the ratio of nitrite to lipoproteins are valid instruments in the clinical follow-up of patients with coronary artery disease. 65 subjects were divided into three groups, including patients with coronary artery disease, silent coronary artery disease and controls. The serum nitrite level and also the ratio of nitrite to high-density lipoprotein were significantly different between the groups. According to the number of obstructed arteries, the serum nitrite level and the ratio of nitrite to high-density lipoprotein were found statistically different between the groups. There was a positive correlation between the serum nitrite level and the ratio of nitrite to high-density lipoprotein and the number of obstructed arteries. In conclusion, the serum nitrite level and ratio of nitrite to high-density lipoprotein may provide a beneficial guide to follow-up the status of patients with coronary artery disease. ©Copyright.