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Yayın Age-related changes in tissue and plasma zinc levels: Modulation by exogenously administered melatonin(TAYLOR & FRANCIS INC, 2008) Oeztuerk, Gueler; Akbulut, K. Gonca; Afrasyap, LaleMelatonin (MEL) is synthesized mainly in the pineal gland and derived from 5-hydroxytryptophan (5-HTP). Zinc (Zn) is one of the most important trace elements in the body. Zn and MEL levels are changed with aging. The aim of this study was to investigate the age-related changes of tissue and plasma Zn levels and effect of MEL administration on these parameters. Male wistar rats received for 3 weeks subcutaneous injection of MEL (10mg/kg). Kidney and pancreas Zn levels in old rats were significantly lower than middle-aged group. Spleen, small intestine, and plasma Zn levels were not different in middle-aged and old rats. On the other hand, MEL treatment increased Zn levels of small intestine and plasma in middle-aged rats. However, kidney, spleen, and pancreas Zn levels were unaffected by MEL treatment.Yayın Mitojenle etkinleşen protein kinazların heterotrimerik G proteinleri ile düzenlenmesi(2013) Küçükkaya, Bahire; Afrasyap, LaleG proteinleri olarak bilinen heterotrimerik G proteinleri ?, ? ve ? alt birimlerinden oluşur. G protein aracılı sinyal iletimi memeli organizmasındaki tüm hücrelerde kullanılır ve duyusal bilginin algılanması, sinaptik iletinin düzenlenmesi, hormon serbestlenmesi ve etkileri, hücre kasılmasının ve göçünün düzenlenmesi, hücre büyümesi ve farklılaşmasının düzenlenmesi gibi farklı fizyolojik fonksiyonlar ile ilişkilidir. G proteinlerinin, ? alt birimleri amino asit benzerliklerine göre temel olarak Gs, Gi, Gq, ve G12 olmak üzere dört aileye ayrılır. G proteinleri enzimler, iyon kanalları ve küçük GTPaz' lar gibi aşağı efektör moleküllerini uyararak, mitojenle-etkinleşen protein kinazlar da dahil pek çok sinyal yolağını düzenlerler. Mitojenle-etkinleşen protein kinaz ailesi gen ekspresyonu, hücre bölünmesi, hücre canlılığı, apopitoz, metabolizma, farklılaşma ve motilite ile ilişkili süreçlerin kontrolündeki sinyal iletimi yolaklarını oluştururlar. Mitojenle-etkinleşen protein kinaz ailesi, klasik mitojenleetkinleşen protein kinazlar olarak adlandırılan ERK1/2, c-Jun N-terminal kinazlar 1, 2 ve 3, p38MAPK a, b, g ve d ve ERK5 ile atipik mitojenle-etkinleşen protein kinazlar olarak adlandırılan ERK3, ERK4 NLK ve ERK7 MAPK' ları içerir. Mitojenle-etkinleşen protein kinaz yolaklarının her biri en üstteki kinazdan itibaren sırasıyla; mitojenle-etkinleşen protein kinaz kinaz kinaz, mitojenle-etkinleşen potein kinaz kinaz, ve mitojenle-etkinleşen protein kinaz olmak üzere üç farklı kinazı içerirYayın Plasma thrombomodulin levels in lung cancer patients(Edizioni Minerva Medica, 1999) Yılmaz, T.; Akman, M.; Tutluoğlu, Bülent; Afrasyap, Lale; Göylüsün, Veli; Çelik, N.BACKGROUND: Thrombomodulin (TM) is a glycoprotein and besides its anticoagulant property it is accepted as an onco developmental antigen. Considering these properties we hypothesised that active TMB might have a role in cancer cell behaviour. METHODS: We measured serum TMB levels by the enzyme immunoassay method in 40 patients with lung cancer and 20 healthy subjects. RESULTS: TMB levels were found as 54.6 +/- 11.5 in controls and 60.9 +/- 31.2 ng/ml in lung cancer patients TM levels were 59.4 +/- 24.2 ng/ml in 24 epidermoid carcinoma patients, 65 +/- 50.2 ng/ml in 10 small cell carcinoma patients and 60 +/- 18.4 ng/ml in 6 adenocarcinoma patients. Patients with stage 4 and distant metastasis had a value of 65 +/- 33.9 ng/ml. No significant differences were found between healthy subjects and cancer patients. Also the differences between 3 groups of patients were insignificant. CONCLUSIONS: It was concluded that serum TMB levels could not be accepted as a tumour marker in lung cancer patients.Yayın Regulation of mitogen activated protein kinases through heterotrimeric G proteins(WALTER DE GRUYTER GMBH, 2013) Kucukkaya, Bahire; Afrasyap, LaleHeterotrimeric G proteins are known as G proteins, consist of alpha, beta, and gamma subunits. G protein mediated signaling is employed by virtually all cells in the mammalian organism and is centrally involved in diverse physiological functions such as perception of sensory information, modulation of synaptic transmission, hormone release and actions, regulation of cell contraction and migration, or cell growth and differentiation. The amino acid identity of the alpha subunits has been used as basis for the classification of G proteins into four families G(s), G(i), G(q), and G(12). G proteins stimulate distinct downstream effectors including enzymes, ion channels and small GTPase, thus regulating multiple signaling pathways including those involved in the activation of mitogen-activated protein kinase pathways. Mitogen-activated protein kinases are a family that constitute signaling pathways involved in processes that control gene expression, cell division, cell survival, apoptosis, metabolism, differentiation and motility. The mitogen-activated protein kinase family includes ERK1/2, c-Jun N-terminal kinazlar 1, 2 ve 3, p38MAPK alpha, beta, gamma, and delta, and ERK5 as classical mitogen-activated protein kinases, and ERK3, ERK4 NLK, and ERK7 as atypical mitogen-activated protein kinases. Each of mitogen-activated protein kinase pathways consists of three distinct kinases, namely an upstream respectively; mitogen-activated protein kinase kinase kinase, mitogen-activated protein kinase kinase and mitogen-activated protein kinase
