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    Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women
    (SPRINGER HEIDELBERG, 2010) Haliloglu, Berna; Aksungar, Fehime Benli; Ilter, Erdin; Peker, Hakan; Akin, Figen Temelli; Ozekici, Umit
    We aimed to investigate whether levels of homocysteine (Hcy), folate, and vitamin B12 are related to bone turnover markers and bone mineral density (BMD) in postmenopausal women. One hundred and twenty postmenopausal women were divided into three groups: osteoporotic, osteopenic and normal, according to the BMD measurements. The age, weight, body mass index (BMI), years since menopause (YSM), gravidity, parity, bone turnover markers [type I collagen C-telopeptides (CTx) and bone-specific alkaline phosphatase (BAP)], serum Hcy, parathyroid hormone (PTH), vitamin B12, folate, calcium and magnesium levels were compared with each other. Twenty-five women had osteoporotic, 42 women had osteopenic, and 53 had normal BMD values. After adjusting for confounding factors, serum Hcy levels were significantly higher in osteoporotic women [adj OR = 38.95 (1.474-1029.88) p = 0.02]. The age, YSM, PTH, CTx and BAP levels were related to serum Hcy in all women (beta = 0.523, p = 0.0001; beta = 0.446, p = 0.001; beta = 0.295, p = 0.005; beta = 0.239, p = 0.026; beta = 0.451, p = 0.001, respectively). Our data showed that vitamin B12, folate and Hcy levels were not related with BMD in postmenopausal women. We think that one of the underlying mechanisms of increased Hcy levels and osteoporosis may be a mechanistic link which cannot detected by BMD or biochemical markers.
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    Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women (vol 281, pg 663, 2010)
    (Springer Heidelberg, 2010) Haliloglu, Berna; Aksungar, Fehime Benli; Ilter, Erdin; Peker, Hakan; Akin, Figen Temelli; Mutlu, Nilgün; Özekici, Umit
    [Abstract Not Available]
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    Serotonin dilemma in postmenopausal women: Is it low or high?
    (ELSEVIER IRELAND LTD, 2008) Haliloglu, Berna; Aksungar, Fehime Berth; Ilter, Erdin; Akin, Figen Temelli; Mutlu, Nilgun; Peker, Hakan; Ozden, Selcuk
    Objective: In this study, we have studied with premenopausal (PM), naturally menopausal (NM) and surgically induced menopausal (SM) women in order to investigate the differences in serum cortisol, dehydroepiandrosterone sulfate (DHEA-S), follicle stimulating hormone (FSH) and estradiol (E2) levels on serum serotonin levels. Methods: Forty premenopausal (36.7 +/- 3.5 years), 40 naturally menopausal (54.2 +/- 8.4 years) and 38 surgically induced menopausal (55.4 +/- 11.2 years) women were included in the study. None of the subjects were using antidepressants or hormone replacement therapy. In NM and SM, years since menopause (YSM) were 3.16 +/- 1.58 and 3.36 +/- 1.89, respectively. Cortisol, DHEA-S, FSH and E2 levels were determined by immunochemiluminisence while serotonin levels were determined by HPLC. Results: Serum serotonin levels in NM women were higher than the other two groups [144.23 +/- 45.29 mu g/L vs 61.35 +/- 37.72 mu g/L in SM women and 98.74 +/- 50.29 mu g/L in PM women]. E2 and DHEA-S were positively correlated, while FSH and cortisol were negatively correlated with serotonin in NM and SM. There was no significant correlation between serotonin and age or YSM. In the PM group, there was no significant correlation between serotonin and the hormones. Conclusion: In conclusion, increased serotonin levels in naturally menopausal women may be a compensatory mechanism to decreased E2 levels as it is postulated that there is strong interaction between E2 and the serotoninergic system. (C) 2008 Elsevier Ireland Ltd. All rights reserved.