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    Cutaneous drug eruptions by current antiepileptics: Case reports and alternative treatment options
    (LIPPINCOTT WILLIAMS & WILKINS, 2008) Sahin, Sevki; Comert, Asuman; Akin, Ozlem; Ayalp, Sunay; Karsidag, Sibel
    Serious cutaneous drug eruptions due to antiepileptics have been defined for many drugs like carbamazepine, diphenylhydantoin, phenytoin and valproate. In recent years, adverse cutaneous reactions due to the current antiepileptic drugs have also been reported. in this paper, two cases are presented: a 48-year-old female receiving gabapentin for postherpetic neuralgia who developed leukocytoclastic vasculitis after 8 weeks and a 23-year-old male receiving lamotrigine for epileptic seizures who developed toxic epidermal necrolysis (TEN) in. 15 days. Alternative therapy approaches with practical suggestions are also discussed.
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    Follicular mucinosis mimicking lichen spinulosus in an 11-year-old boy
    (JOHN LIBBEY EUROTEXT LTD, 2007) Comert, Asuman; Akin, Ozlem; Demirkesen, Cuyan
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    Generalized pruritus treated with narrowband UVB
    (BLACKWELL PUBLISHING, 2007) Seckin, Dilek; Demircay, Zeynep; Akin, Ozlem
    Background Narrowband UVB phototherapy has been increasingly used in a variety of dermatological diseases. We planned to evaluate its efficacy in generalized pruritus in this prospective study. Methods Forty-six patients were included and then divided into two groups: group 1 and group 2 consisted of patients with uremic pruritus and "idiopathic pruritus", respectively. Phototherapy was given three times a week. Efficacy assessments were made by means of visual analog scale (VAS) and pruritus grading score. Results Thirty-five patients completed the treatment. Mean VAS decreased from 8.2 +/- 1.5 to 3.6 +/- 3 in group 1 and from 7.1 +/- 2.3 to 2.3 +/- 2.8 in group 2 (P < 0.0001). Mean percentage of change in VAS was 54.2% (95% CI 32.6-75.9) and 67.9% (95% CI 53.8-81.9) in group 1 and group 2, respectively. Mean number of treatments was 22 in both groups. Mean cumulative UVB dose was 24,540 mJ/cm(2) and 20,801 mJ/cm(2) in group 1 and group 2, respectively. Conclusion Narrowband UVB is an effective and well-tolerated treatment option for patients with generalized pruritus.