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Presence of chronic varicose veins related to increased serum ceruloplasmin levels in adults: a cross sectional study
(John Wiley & Sons, Ltd, 2015) Sezen, H.; Çeviker, K.; Savik, E.; Demir, Deniz; Koçarslan, A.; Aksoy, N.; Demir, Deniz
Background: One-fifth of the population suffers from varicose veins (VV). Varicose veins are not only a serious cosmetic and emotional problem, but can also result in loss of limbs. Our aim was to evaluate the relationship between serum Ceruloplasmin (Cp) levels and VV. Materials and methods: Thirty-five patients with superficial and symptomatic varicose veins of the lower extremities, and 35 age and sex matched control subjects were included in this study. Ceruloplasmin levels were measured by Erel’s method, an automated and calorimetric method. Results: In the VV group, Cp was significantly higher than in the control group (p = 0.012). No other factor was associated with serum Cp levels. Before and after surgical treatment, serum Cp levels were similar in the patient group. Discussion: This study demonstrated higher serum Cp levels in patients with VV, which decreased slightly, though not statistically significant, after surgical treatment