Yazar "Balci, Mustafa Bahadir Can" seçeneğine göre listele

Listeleniyor 1 - 6 / 6
  • Küçük Resim Yok
    Yayın
    The comparative evaluation of apoptosis produced by leuprolide or orchiectomy on rat prostate tissue
    (PAGEPRESS PUBL, 2015) Cakiroglu, Basri; Hazar, Aydin Ismet; Eyyupoglu, Seyit Erkan; Balci, Mustafa Bahadir Can; Sinanoglu, Orhun; Tuzlali, Pinar
    Introduction: Organisms are constantly in a balance meaning that while new cells are produced, some of the older ones die which takes place in 2 ways: necrosis or apoptosis. Apoptosis is the programmed cellular death triggered by intrinsic or extrinsic stimuli. In this study we have evaluated the apoptosis of prostate tissue generated by surgical or medical orchiectomy. Material and Method: In this experimental study, we used 36 adult male rats that were evaluated in 3 groups. The first group (Group 1) consisted of 12 rats that had bilateral orchiectomy; the second group (Group 2) included 12 rats that were given leuprolide acetate and the third group (Group 3) consisted of 12 control rats. Immunohistochemical staining of the prostate of all rats was performed and the presence of glandular atrophy and apoptosis were evaluated in the three groups. The statistical differences between the two groups were evaluated by the Fisher exact test. Results: Glandular atrophy was not determined in any rat of the control group, and the apoptotic staining was in the normal limits in all the control rats. In Leuprolide group, glandular atrophy was mild in 7 cases, and moderate in 3 rats. In 2 rats of the Leuprolide group, atrophy was not demonstrated. In surgical orchiectomy group, glandular atrophy was present in all cases. Atrophy was observed as cystic atrophy. Statistical analysis with the Fisher exact test revealed that glandular atrophy was statistically significantly more common in surgical orchiectomy group compared with Leuprolide group (p = 0,012). Conclusion: If the aim of treatment in androgen dependent prostatic adenocarcinoma or benign prostate hypertrophy is the construction of a robust apoptosis, bilateral orchiectomy generates a more powerful apoptosis compared with Leuprolide.
  • Küçük Resim Yok
    Yayın
    The effect of inclined position on stone free rates in patients with lower caliceal stones during SWL session
    (PAGEPRESS PUBL, 2015) Cakiroglu, Basri; Sinanoglu, Orhun; Tas, Tuncay; Hazar, Ismet Aydin; Balci, Mustafa Bahadir Can
    Objective: To compare the outcomes of shock wave lithotripsy (SWL) combined with inclined position and SWL alone in patients with lower pole calyx stones. Methods: Seven hundred forty patients who underwent SWL treatment for lower pole renal stones with a total diameter of 2 cm or less were prospectively randomized into two groups. They were comparable in terms of age, sex, and stone diameters. Patients with lower calyceal stones (4-20 mm) were randomized to SWL (368 patients) or SWL with simultaneous inclination (372 patients) with 30o head down Trendelenburg position). Shock wave and session numbers were standardized according to stone size. Additional standardized shock waves were given to patients with stone fragments determined by kidney urinary bladder film and ultrasound at weeks 1, 4, 10. Results: The overall stone free rate (SFR) was 73% (268/368) in patients with SWL alone and 81% (300/372) in SWL with inclination at the end of 12th week (p = 0.015). No significant adverse events were noted in both treatment groups. Conclusion: Simultaneous inclination of patients during SWL session increase SFR in lower caliceal stones significantly compared to SWL treatment alone.
  • Küçük Resim Yok
    Yayın
    Effectiveness of Shock Wave Lithotripsy (SWL) Treatment of Kidney Stones Larger than Two Centimeter
    (Aves, 2012) Çakıroğlu, Basri; Hazar, A. Ismet; Balci, Mustafa Bahadir Can; Sinanoğlu, Orhun; Özkan, Arif; Nuhoğlu, Baris
    Objective: We aimed to investigate the effectiveness of SWL in the treatment of renal stones over 2 cm retrospectively. Methods: One hundred and nine patients (80 men and 29 women), who had been treated with ESWL because of 2cm or greater renal stones between January 2007 and January 2011, were enrolled to the study. Participants with a renal stone sized between 2 and 2.5 cm were grouped as group 1 and the others with a renal stone over 2.5 cm were grouped as group 2. We comapared the quantity of shock wave, analgesia requirement, efficacy and side effects between groups. A new generation ESWL device, Storz Medical Modulith SLK, was used for treatment. Data of the patients was analysed retrospectively. ESWL was considered successful if residual stone pieces smaller than 3 mm were detected in a 3 months period. Results: Renal stones were cleaned successfully in 100 (91.7%) patients who had been followed up for three months. There was no significant difference between group 1 and 2 in terms of residual stones. A patient required additional treatment (1.69%) in group 1, while 4 patients (8%) required additional treatment in group 2. Development rate of stone street in group 1 and 2 was 3.38% (2 patients) and 10% (5 patients), respectively. Five patients in both 2 groups required flexible uroterorenoscopy due to residual stones. Analgesic requirement rates were similar in both groups. 82 (75.2%) patients had not required anlgesic, but 27 participants had been administered intramuscular diclofenac or Tradamol. Neither general, spinal or epidural anestesia nor sedation and narcotic analgesia was administered. Haematuria rates in group 1 and 2 were 15.2% and 36%, respectively. There was also no significant difference between groups in terms of skin rash rates. Conclusion: New generation electromagnetic ESWL provides effective and reliable treatment with minimal complications in patients with renal stones over 2 cm.
  • Küçük Resim Yok
    Yayın
    The histology and the proapoptotic control in the ipsilateral and the contralateral testes following unilateral vasectomy
    (PAGEPRESS PUBL, 2015) Hazar, Aydin Ismet; Cakiroglu, Basri; Sakalli, Ertan; Balci, Mustafa Bahadir Can; Eyyupoglu, Erkan; Tas, Tuncay; Sinanoglu, Orhun; Tuzlali, Pinar; Cilesiz, Nusret Can
    Objective: The aim of this study was to enlighten both the testicular histology and the genetic aspects of the apoptotic process. Thus an experimental study was designed with a model of unilateral vasectomy. Methods: Twenty-two adult male rats were used and 4 main groups were formed. The first (A), the second (B), the third (C), and the fourth group (D) consisted of 4, 4, 4 and 10 rats respectively. Rats in group A had sham operation while rats in other groups (B, C, D) underwent left vasectomy operation including binding of ductus deferens with a 3/0 silk and cutting a minimum of 1 cm part while preserving the vascular structure under 9x magnification. Rats undergoing unilateral vasectomy were sacrificed at the 1st, 2nd and 8th weeks and their testicular structure and proapoptotic gene proteins were compared with that of the control group undergoing sham operation. Results: We found that vasectomy gradually caused destruction and both ipsilateral and contralateral testicles were affected showing initial apoptosis. Conclusion: The procedure causes destruction in the testicular structure by causing bilateral intratubular germ cell necrosis, unilateral obstruction, increase in the tubular pressure and processes that are aggravated by some probable autoimmune reactions.
  • Küçük Resim Yok
    Yayın
    Monosymptomatic nocturnal enuresis caused by seasonal temperature changes
    (E-CENTURY PUBLISHING CORP, 2014) Tas, Tuncay; Cakiroglu, Basri; Hazar, Aydin Ismet; Balci, Mustafa Bahadir Can; Sinanoglu, Orhun; Nas, Yunus; Yilmazer, Fazli
    Background: Primary nocturnal enuresis is the most frequent urologic complaint among pediatric patients. Enuresis is believed to have a complex etiology involving genetic, somatic, and behavioral factors. We study the relationship between seasonal temperature changes effect and monosymptomatic nocturnal enuresis (MNE). Methods: Between 2011 and 2012, a total of 75 children with primary MNE selected from urology and pediatry clinics were included in this study. All of the children underwent physical examinations, urine analyses, urinary ultrasounds, and direct urinary graphs. We evaluated the enuresis ratio for the summer (the hot season from June to September) and winter (the cold season from December to March) months in nightly, weekly, and monthly intervals via prepared questionnaires. Results: Of the 75 study participants, 45 were boys (60%) and 30 were girls (40%). The age range was 6-16 years (mean 10.3 +/- 2.0 years). We observed a difference in the ratio of enuresis data between the summer and winter months in 29 males and 19 females, which totals 48 of the 75 MNE patients evaluated in this study. There was a statistically significant difference noted in monthly enuresis ratio in the summer and winter (p<0.0001). We observed a significant difference in quality of life, and this difference caused considerable emotional discomfort for the patients. Conclusion: In the winter months, the nightly, weekly, and monthly ratios are higher in children with MNE. This increase causes a decrease in the quality of life of these children.
  • Küçük Resim Yok
    Yayın
    Penile Mondor's Disease Induced by Vigorous Sexual Activity: Two Cases, Two Different Approaches
    (ORTADOGU AD PRES & PUBL CO, 2012) Aydin, Memduh; Tas, Tuncay; Gursoy, Gokhan; Sinanoglu, Orhun; Balci, Mustafa Bahadir Can; Hazar, Aydin Ismet; Nuhoglu, Baris
    Penile Mondor's disease is a painless superficial induration due to thrombosis of penile superficial dorsal vein. Etiological factors for superficial dorsal penile vein thrombosis include trauma, vigorous sexual activity, pelvic tumors and a distended bladder. Doppler ultrasonographic evidence of thrombotic dorsal penile vein is diagnostic for penile Mondor's disease. Two cases with Mondor's disease of the penis due to brutal sexual intercourse are reported here. The first patient's thrombosis resolved spontaneously whereas in the second one anti-inflammatory and heparinoid agents were applied. The treatment should primarily be based on temporary sexual abstinence, and in case of no response treatment with non-steroid anti-inflammatory agents, local anticoagulants should be administered. Larger series are needed to determine whether initial observation is appropriate for all patients with penile Mondor's disease.