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    Evaluation of platelet serotonin levels in migraine without aura [Aurasiz migrende trombosit serotonin düzeylerinin deg erlendirilmesi]
    (2012) Ayalp S.; Sahin Ş.; Benli Aksungar F.; Karsj¸dag S.
    Objectives: The relation between migraine and serotonin levels is not clear. Plasma serotonin levels in migraineurs were investigated in previous studies. However, in the current literature, it is stated that measurement of serotonin level in platelets is more reliable. Methods: Thirty female migraine without aura patients who were diagnosed according to the criteria of the International Headache Society and 20 healthy controls were enrolled in the study. The Hamilton depression scale (HAM-D) was applied to all subjects and those scoring 10 and above were not considered. Fasting venous blood samples were taken from subjects in the morning. Platelet rich and poor plasma were prepared. The samples were measured with high performance liquid chromatography and platelet serotonin concentration was calculated. Results: Our results suggest that migraineurs have significantly low platelet serotonin concentration compared to controls. The ratio of family history of migraine in the patient group was clearly higher than in controls. HAM-D scores were significantly higher in migraineurs than in the control group. Although there was a weak correlation between low serotonin levels and attack duration and number, there was no statistical significance. Conclusion: Our results suggest the role of heredity and low serotonin levels in the migraine pathogenesis. Even though all subjects enrolled in the study had scores under the depression level, HAM-D scores were higher in migraineurs than controls. This may indicate the presence of subclinical depression associated with low serotonin levels in migraineurs. Extensive studies including both serotonin and other markers duringpain and pain-free periods are needed.
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    An infectious mononucleosis case [Bir enfeksiyöz mononükleoz olgusu]
    (Turkiye Klinikleri, 2007) Eren Topkaya A.; Benli Aksungar F.; Özakkaş F.; Çapan Akinci N.
    Epstein-Barr virus (EBV) is transmitted through intimate contact and the portal of entry is usually the lympho-epithelial cells lining the oral cavity where a persistent infection is established. The virus-host interaction is usually sub-clinical in young children. A 20-month-old male presented with long-lasting high fever of unknown origin. Generalized lymphadenopathy and an exantematous rash on the back of the patient were detected on physical examination. Antibodies against EBV, rubella, CMV and HSV were detected in the initial blood samples and the avidity of IgG class antibodies was evaluated. Low avidity of EBV-VCA IgG was detected and, other serological tests for EBV were performed. Infectious mononucleosis was diagnosed upon positive test results. Previous studies reporte that, during infections by viruses that may cause latent infections, polyclonal B lymphocytes are activated, producing antibodies against other viruses. As a result, in patients with exanthematous rash, IgM and IgG class antibodies along with avidity tests should be evaluated for differential diagnosis. Copyright © 2007 by Türkiye Klinikleri.