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    CD4+CD25(high), CD8+CD28-cells and thyroid autoantibodies in breast cancer patients
    (TERMEDIA PUBLISHING HOUSE LTD, 2014) Bilgi, Oguz; Karagoz, Bulent; Turken, Orhan; Gultepe, Mustafa; Ozgun, Alpaslan; Tuncel, Tolga; Emirzeoglu, Levent; Celik, Serkan; Muftuoglu, Tuba; Kandemir, Emin Gokhan
    Aim of the study: To investigate the percentage of CD4+CD25(high) cells (including Treg cells) and CD8+CD28- cells in breast cancer patients with and without high levels of autoimmune thyroid antibodies. Material and methods: Thirty-five women with breast cancer (9 of them having high thyroid antibodies) and fourteen healthy subjects were enrolled in this study. Flow cytometry was used to count CD4+CD25(high) cells and CD8+CD28- suppressive cells (CD8 cell subtypes). Results: In the patient group, the percentage of CD28 cells in CD8+ lymphocytes were higher [67.50% (55.1180.33) vs. 51.56% (42.5766.38); p = 0.021] and the percentage of CD28+CD45RO- cells (memory cells) in CD8+ lymphocytes were lower than in the control group. CD4+CD25(high) cell percentage in CD4+ lymphocytes was elevated in the patient group [6.44% (4.528.74) vs. 2.97% (1.724.34); p < 0.001]. When the cytometric parameters were compared between patients (with high vs. normal thyroid antibodies), the distribution of CD8+ cell subgroups was also similar. CD4+CD25high cells among CD4+ lymphocytes were decreased in patients with high levels of thyroid antibodies [5.19% (3.426.17) vs. 6.99% (4.829.95); p = 0.043]. Conclusions: CD4+CD25(high) cells may play a role in autoimmunity of breast cancer patients, and may be a predictive marker. Advanced studies which evaluate the possible links between regulatory cells and autoimmunity should be established in cancer patients.
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    The Prognostic Significance of Comorbidity and Relation of Comorbidity with the Other Prognostic Factors in Patients with Non Small Cell Lung Cancer
    (AKAD DOKTORLAR YAYINEVI, 2009) Ozgun, M. Alpaslan; Karagoz, Bulent; Bilgi, Oguz; Kandemir, E. Goekhan; Turken, Orhan
    Comorbidities often be encountered in lung cancer patients. However, the relationship between lung cancer and comorbidity has not been investigated sufficiently yet. In this study, the prevelance of comorbidity in 358 patients with non small cell lung cancer diagnosed in Gulhane Military Medical Academy Haydarpasa Training Hospital was reviewed and its association with other known prognostic factors and impact of comorbidity on the prognosis was investigated. Comorbidity was significantly correlated with age, disease stage and performance status (p= 0.0001). There was no association of comorbidity grade with sex and histopathological type (p= 0.9, p= 0.5). Univariate analysis demonstrated significant associations between overall survival and comorbidity, as well as, age, disease stage, performans status and histopathological type (p= 0.00001). In multivariate analysis, high comorbidity grade, as independent from the other prognostic factors, influences overall survial negatively (p= 0.0001). As a result, it was found that comorbidity is an independent poor prognostic factor in patients with non small cell lung cancer.