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    Bifidobacteria and Mucosal-Associated Invariant T (MAIT) Cells: A New Approach to Colorectal Cancer Prevention?
    (Mdpi, 2019) Bozkurt, Hüseyin Sancar; Quigley, Eamonn M. M.
    Colorectal cancer is the most preventable form of cancer worldwide. The pathogenesis of colorectal cancer includes gut inflammation, genetic and microbial composition factors. Impairment of the gut microbiota has been associated with development of colorectal cancer. The genus Bifidobacterium is an important component of the commensal gut microbiota. Bifidobacteria are considered to have important roles in multiple homeostatic functions: immunologic, hormonal and metabolic. Mucosal-associated invariant T cells (MAIT) are components of the immune system involved in protection against infectious pathogens and regulate the pathogenesis of various inflammatory diseases and, potentially, colorectal cancer. Engagement between Bifidobacterium and MAIT cells could exert a beneficial effect on colorectal cancer prevention and treatment.
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    Biodegradation of microplastic by probiotic bifidobacterium
    (Inderscience Enterprises Ltd, 2022) Bozkurt, Hüseyin Sancar; Yoruklu, Hulya Civelek; Bozkurt, Kutsal; Denktas, Cenk; Bozdogan, Altan; Özdemir, Orhan; Özkaya, Bestami
    A growing accumulation of microplastics has become a severe environmental and health issue. Scientific reports on biodegradation of microplastics by microorganisms have sprung up, and these offer a possibility to develop different microbial biodegradation approaches for microplastics. Bifidobacterium infantis is a probiotic commensal heterotrophic anaeorobic bacterium that regulates the intestinal microbiota. In this study, we have comprehensively analysed the probiotic Bifidobacterium infantis microorganism and that is able to degrade polypropylene, which is generally used as synthetic plastic in various atmospheric conditions. Microplastic biodegradation of probiotic bifidobacterium occurs in an aerobic environment and FTIR spectrum of biofilm structure result provides that probiotic bifidobacterium uses polypropylene as an energy and carbon source. The microbial biofilm structure that emerges as a result of biodegradation is a bio-based compound that prevents the growth of pathogenic bacteria. The probiotic bifidobacterial biodegradation of microplastics, which is a global environmental problem threatening human health, is promising.
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    Development and characterization of sodium alginate/bifidobacterium probiotic biohybrid material used in tissue engineering
    (Wiley, 2022) Denktaş, Cenk; Baysoy, Derya Yılmaz; Bozdogan, Altan; Bozkurt, Hüseyin Sancar; Bozkurt, Kutsal; Özdemir, Orhan; Yılmaz, Mehmet
    Mechanical properties are crucial for biodegradable and/or non-biodegradable materials used in tissue engineering applications. In this study, bio-hybrid films were produced by using both Bifidobacterium animalis subsp. lactis BB-12 probiotic strain and Bifidobacterium infantis in combination with sodium alginate (SA), which demonstrates biocompatibility and facilitated gelation properties. Bio-hybrid films were characterized by using different methods. Based on the spectroscopic and mechanical analysis, it was found that mechanical strength increased in films produced by adding Bifidobacterium infantis in SA while this increase was relatively lower as compared to those containing Bifidobacterium animalis subsp. lactis BB-12 as cross-linking ratio increases. Besides, bacteria contained in bio-hybrid films increased the percentage of amorphous zone of SA in SA/bacteria films, which reduced the crystallinity ratio. This indicated that crystalline chains contained in the structure of SA are degraded by bacteria.
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    A new treatment for ulcerative colitis: Intracolonic Bifidobacterium and xyloglucan application
    (SageJournals, 2020) Bozkurt, Hüseyin Sancar; Kara, Banu
    Ulcerative colitis (UC) pathogenesis includes the altered gut microbiota, environmental factors, and human immune and genetic predisposition. Recently, its association with reduced bifidobacteria quantity in the microbiota is reported. Xyloglucan, a plant-based prebiotic oligosaccharide, causes increase in bifidobacteria quantity. In this article, we share the results of our UC cases treated by intracolonic single-dose administration ofBifidobacterium animalissubsp.lactisand xyloglucan combination. Intracolonic single-dose administration of 200 billion colony-forming units (CFUs) ofB. animalissubsp.lactisand 4 g of xyloglucan combination was administrated to 10 severe UC patients, who were either unresponsive or had inadequate response to treatment. All patients continued treatment after the procedure. Treatment responses were evaluated by colonoscopic, laboratory, and clinical examination after 6 weeks. Intracolonic single-dose administration ofB. animalissubsp.lactisand xyloglucan was found effective in the mucosal healing and resolution of colonic symptoms in UC patients. Intracolonic administration ofB. animalissubsp.lactisand xyloglucan in UC is a new single-strain and strain-specific prebiotic combination method. It is easy to apply and has no observable side effect. Its effectiveness on mucosal healing could be attributed to the enhancement of non-stimulatory status and biodiversity in colonic mucosa. Nonetheless, it is still necessary to develop diagnostic strategies to determine the patients to whom this method would be the most applicable.
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    Portabl pulse oxymetry and contrast echocardiography in hepatopulmonary syndrome diagnosis / Hepatopulmoner sendrom tanısında portabl pulse oksimetre ve kontrast ekokardiyografi
    (Maltepe Üniversitesi, 2022) Bozkurt, Hüseyin Sancar
    Aim: The aim of this study is investigating hepatopulmonary syndrome’s (HPS) diagnosis in cirrhosis patients with ortodeoxy symptom by portabl pulse oxymetry and transthoracic echocardiography with contrast enhancement. Material and Methods: Ninety five (95) patients (67/28 M/F) with the diagnosis of cirrhosis were included into the study. Mean age of the patients was 52,28±12,0. Measurements of portabl pulse oximetry were obtained in a supin position and in a seated position breathing room air. The suitable patients’ response to oxygen therapy with nasal cannula was evaluated. The patients with hypoxaemia (Sa,02<%94) in seated position were investigated HPS by transthoracic echocardiography with contrast enhancement. Results: Eight (8) patients defined HPS had hypoxaemia in seated position with pulse oxymetry and positive contrast echocardiography. Four patients (4) had type I HPS and four patients (4) had type II HPS. Conclusion: In conclusion, eight of 95(%8,4) patients had HPS. Patients with HPS were old age and were in Child B and C class. In cirrhosis patients with hypoxaemia in seated position, further studies are needed to investigate HPS.