Yazar "Bulur, Isil" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Yayın
    The efficacy and safety of omalizumab in refractory chronic spontaneous urticaria: real-life experience in Turkey
    (DERMATOVENEROLOGICAL SOC SLOVENIA, 2018) Bulur, Isil; Baskan, Emel Bulbul; Ozdemir, Mustafa; Balevi, Ali; Goncu, Emek Kocaturk; Altunay, Ilknur; Gonul, Muzeyyen; Ergin, Can; Ertam, Ilgen; Erdogan, Hilal Kaya; Bilgin, Muzaffer; Erdem, Mustafa Teoman
    Introduction: This study used real-world data to evaluate the effectiveness and reliability of omalizumab in treating recalcitrant chronic spontaneous urticaria in Turkish patients. Methods: Study data were collected retrospectively from eight tertiary-care hospitals in Turkey. This study included 132 patients with chronic spontaneous urticaria that were resistant to H-1 antihistamine treatment in a dose up to four times the licensed dose and were treated with 300 mg/month of omalizumab for 6 months. Results: The mean weekly urticarial activity score (UAS(7)) after omalizumab treatment improved significantly compared to the pretreatment score (p < 0.001). Treatment response was detected primarily in the 1st and 2nd months after treatment. No significant association was observed between omalizumab's treatment effectiveness and disease-related parameters or laboratory data. The mean dermatology life quality index was 23.12 +/- 6.15 before treatment and decreased to 3.55 +/- 3.60 6 months after treatment (p < 0.001). No side effects were reported in 89.4% (118) of the patients. Conclusion: This study showed that UAS(7) decreased significantly and quality of life improved in omalizumab-treated patients. Moreover, treatment effectiveness was mainly observed in the first 2 months after treatment. However, no association was observed between omalizumab treatment effectiveness and disease-related parameters or laboratory data.
  • Küçük Resim Yok
    Yayın
    Evaluation of Healthy Lifestyle Behaviors in Psoriasis Patients
    (Kare Publ, 2021) Deniz, Fatma; Altunay, İlknur Kivanc; Özkur, Ezgi; Cerman, Asli Aksu; Erdoğan, Hilal Kaya; Bulur, Isil
    Objectives: The purpose of our study was to compare healthy lifestyle behaviors between psoriasis patients and healthy controls. Methods: This case- control study included 80 psoriasis patients and 80 sex- and age- matched healthy controls aged over 18. Participants completed the socio-demographic data form and the Health-Promoting Lifestyle Profile II (HPLP-II). The HPLP-II consists of 52 items and measures six components of health-promoting behavior outcomes: Nutrition, physical activity, health responsibility, spiritual growth, interpersonal relations, and stress management. Higher scores show that the individual applies the specified health behaviors at a high level. Results: HPLP-II total scores were 128.3 +/- 21.1 in patient group and 132.5 +/- 22.3 in control group. Based on the scores, psoriasis patients showed a moderate level of health-promoting lifestyle, while controls showed a good level of health-promoting lifestyle. Spiritual growth score of patients (mean +/- SD = 25.6 +/- 4.9) was statistically lower than the controls (mean +/- SD = 27.3 +/- 4.5) (p=0.040). In addition, spiritual growth score and disease duration were negatively correlated in the patient group (r=-0.287, p=0.01). Furthermore, nutrition score of those with additional comorbidity was significantly higher than those with psoriasis alone in patient group (p=0.002). Conclusion: This is the first study to compare healthy lifestyle behaviors of psoriasis patients and healthy volunteers in Turkish population. The task of dermatologists is not only the medical treatment of psoriasis lesions but also questioning patients' lifestyle behaviors and supporting the development of healthy behaviors in patients.
  • Küçük Resim Yok
    Yayın
    Evaluation of the Relationship Between T Regulatory Cells and Vitamin D Levels in Chronic Spontaneous Urticaria
    (GALENOS YAYINCILIK, 2018) Bulur, Isil; Erdogan, Hilal Kaya; Yigitaslan, Semra; Akay, Iga Meltem; Saracoglu, Zeynep Nurhan
    Objective: T regulatory (Treg) cells play a role in autoimmunity and vitamin D is one of the factors involved in regulation of Treg cells. In this study, it is aimed to evaluate the relationship between Treg cells and disease-related parameters and serum vitamin D levels in chronic spontaneous urticaria (CSU) patients. Methods: The percentage of Treg cells were evaluated by flow cytometric analysis and serum 25 hydroxy vitamin D (25(OH)Vit D) levels were determined by commercial available ELISA kit. Results: Thirty eight CSU patients and 30 healthy controls were included in the study. The percentage of CD4(+)CD25(+) and CD4(+)FOXP3(+) T cells in the patient group were found lower than in the control group (p=0.018, p=0.000). No difference was detected between groups in terms of the percentage of CD4(+)CD25(+)FOXP3(+) T cells and the 25(OH) Vit D levels (p=0.192, p=0.218). There was no significant relationship between disease duration, weekly urticaria activity score, autologous serum skin test (ASST), serum 25(OH) Vit D levels and the percentage of Treg cells in CSU patients. Conclusion: The percentage of CD4(+)CD25(+) and CD4(+)FOXP3(+) T cells in CSU patients were observed to be lower than control group independent from the serum 25(OH)Vit D levels, ASST positivity, disease duration and severity. This result suggests that Treg cells are one of the factors involved in the pathogenesis of CSU.