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Yayın Bone turnover and maternal 25(OH) vitamin D3 levels during pregnancy and the postpartum period: should routine vitamin D supplementation be increased in pregnant women?(ELSEVIER SCIENCE BV, 2011) Haliloglu, Berna; Ilter, Erdin; Aksungar, Fehime Benli; Celik, Aygen; Coksuer, Hakan; Gunduz, Tonguc; Yucel, Erdal; Ozekici, UmitObjective: To investigate the relationship between 25(OH) vitamin D3 levels and maternal bone turnover during pregnancy and lactation. Study design: Thirty pregnant women and 30 healthy non-pregnant controls were included the study. The pregnant women were examined in the 12th, 25th and 32nd gestational weeks and 6 weeks after delivery. The controls were examined once. Serum concentrations of 25(OH) vitamin D3, parathyroid hormone (PTH), cross-linked C-terminal telopeptide of type I collagen (CTX), calcium, and phosphate were measured. Results: In the 32nd week and the postpartum period, 25(OH) vitamin D3 deficiency rates were 13.3% and 333%, respectively. Serum 25(OH) vitamin 03 levels were below the detection limit in 10% and 33%, respectively, of the same subjects. In the control group, rates of 25(OH) vitamin D3 deficiency and "below detection limit" were 30% and 23%, respectively. While 25(OH) vitamin 03 and CTX levels were not correlated to each other in the first trimester, a negative correlation was found in the 2nd and 3rd trimesters and the postpartum period between 25(OH) vitamin 03 and CTX levels (r = -0.472, p = 0.048; r = -0.893, p < 0.0001, r = -0.881, p < 0.001, respectively). No correlation between 25(OH) vitamin D3 and CTX levels was found in controls. Conclusion: We consider that 25(OH) vitamin D3 supplementation of women could both decrease maternal bone resorption and lead to enhanced bone mass in offspring during later life. Since women are prone to 25(OH) vitamin D3 insufficiency, we suggest higher doses of 25(OH) vitamin D3 should be given to pregnant subjects. (C) 2011 Elsevier Ireland Ltd. All rights reserved.Yayın Comparison of uterine artery blood flow with levonorgestrel intrauterine system and copper intrauterine device(ELSEVIER SCIENCE INC, 2011) Haliloglu, Berna; Celik, Aygen; Ilter, Erdin; Bozkurt, Serpil; Ozekici, UmitBackground: As a contraceptive method, we investigated whether the levonorgestrel-releasing intrauterine system (LNG-IUS) has any effect on uterine artery blood flow when compared with copper intrauterine device (IUD). Study Design: Sixty women with copper IUD and 60 women with LNG-IUS were included in the study. The age, gravidity, parity, body mass index (HMI) and menstrual flow pattern using a pictorial chart were recorded. All women were assessed by ultrasonography at the preinsertion period and 1 year after insertion. The pulsatility and resistance indices (PI and RI, respectively) of the uterine artery and endometrial thickness were evaluated in the preinsertion and postinsertion periods. Results: In copper IUD users, preinsertion and postinsertion ultrasonographic assessments were not significantly different. However, postinsertion RI was significantly higher compared with preinsertion RI in LNG-IUS users (p=.001). The PI was also increased 1 year after insertion, but it did not reach statistically significant levels (p=.08). Endometrial thickness was also significantly decreased in the postinsertion period in women with LNG-IUS (p=.04). Conclusion: The significant increase in uterine artery RI in LNG-IUS users 1 year after insertion might be due to its local progestational effects. It might also indicate the mechanism of the LNG-IUS in reducing menstrual blood flow. (C) 2011 Elsevier Inc. All rights reserved.Yayın Evaluation of cervical cytological abnormalities in Turkish population(MEDKNOW PUBLICATIONS, 2012) Atilgan, Remzi; Celik, Aygen; Boztosun, Abdullah; Ilter, Erdin; Yalta, Tulin; Ozercan, ResatIntroduction: Cervical cancer is one of the most common female malignancy with high mortality rates in developing countries. Our purpose was to determine the prevalence of cervical cytologic abnormalities in population (strict Islamic religious area) and the detection rate of epithelial abnormalities by cervical cytology (CC). Materials and Methods: A total of 32,026 conventional pap smear tests collected between January 2006 and January 2010 from three hospitals are retrospectively analyzed. Results: Total of 900 (2.8%) cases had epithelial abnormalities. The numbers and rates of epithelial abnormalities were as the followings: Atypical squamous cell of undetermined significance (ASCUS; n=615 [1.9%]); atypical squamous cell suspicious for high-grade squamous intraepithelial lesion (ASC-H; n=27 [0.1%]); atypical glandular cell of undetermined significance (AGUS; n=73 [0.2%]); low-grade squamous intraepitelial lesion (LSIL; n=147 [0.5%]); high-grade squamous intraepithelial lesion (HSIL; n=35 [0.1%]); and squamous cell carinoma (SCC; n=3 [0.0%]). Conclusion: The prevalence of cervical cytological abnormality in our study was 2.8%. Recently, some conflicting results from the same population were published. More prospective studies with larger numbers are needed.Yayın Fluid intake and voiding parameters in asymptomatic Turkish women(SPRINGER LONDON LTD, 2012) Haliloglu, Berna; Peker, Hakan; Ilter, Erdin; Celik, Aygen; Kucukasci, Meryem; Bozkurt, SerpilFor an accurate evaluation of bladder diaries, we aim to investigate normal urinary habits and determining factors on functional bladder capacity, frequency, and 24-h volume in the bladder diaries of asymptomatic women. One-hundred and fifteen asymptomatic women who recorded a 24-h bladder diary were included in the study. Linear regression analyses were used to explore associations between diary values and patient characteristics. Total number of voids was related to age, body mass index, total voided volume, total fluid intake, total diuresis rate, and maximum fluid intake in one go. Maximum, average, and minimum volumes per void were found to be related to body mass index, total voided volume, total fluid intake, total diuresis rate, and maximum fluid intake. When we used multiple regression analysis, only maximum fluid intake was found to be related to the total number of voids, maximum, average, and minimum volumes per void. Maximum fluid intake rather than total voided volume seems to be an important determinant factor for total number of voids and functional bladder capacity.Yayın Laparoscopic Sacrohysteropexy in aWoman at 12 Weeks' Gestation(ELSEVIER SCIENCE INC, 2018) Peker, Berna Haliloglu; Ilter, Erdin; Peker, Hakan; Celik, Aygen; Gursoy, Ali; Gunaldi, Onur…Yayın Negative correlation between D-dimer and homocysteine levels during pregnancy and the postpartum period a prospective study(ELSEVIER SCIENCE BV, 2010) Haliloglu, Berna; Aksungar, Fehime Benli; Celik, Aygen; Ilter, Erdin; Coksuer, Hakan; Ozekici, UmitObjective There have been conflicting data about the role of increased levels of homocysteine (Hcy) on haemostatic system We aim to investigate prospectively the relation between serum Hcy levels and changes in haemostatic system in pregnancy and postpartum period Study design Sixty-eight healthy pregnant women were included in the study Blood samples were obtained in the 11th gestational week 25th gestational week 32nd gestational week and postpartum 4th week The haemoglobin levels white blood cell count (WBC) platelet count activated partial thromboplastin time (aPTI-) prothrombin time (PT) fibrinogen D-dimer Hcy vitamin B12 and folate levels were measured Results Serum Hcy levels were negatively correlated with D-dimer levels (r = -0 57 p < 0 0001) The highest levels of D-dimer (1046 62 +/- 322 01 ng/ml) were achieved in the third trimester and the lowest levels of serum Hcy (4 45 +/- 123 mmol/1) were detected in the same trimester In postpartum fourth week D dimer levels were decreased to normal levels (238 27 +/- 198 59 ng/ml) while the serum Hcy levels were reached to the highest levels (7 99 +/- 1 36 mmol/1) Conclusion The negative correlation between Hcy and D-dimer levels may be a compensatory mechanism to maintain the normal haemostatic balance in pregnancy Hence possible advantage of low Hcy levels in pregnancy may be to prevent undesired thrombosis (C) 2010 Elsevier Ireland Ltd All rights reservedYayın Plasma cell vulvitis: A vulvar itching dilemma(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2012) Celik, Aygen; Hallioglu, Berna; Tannover, Yonca; Iiter, Erdin; Gunduz, Tonguc; Ulu, Ipek; Midi, Ahmet; Ozekici, Umit…Yayın Voice and Speech Changes in Various Phases of Menstrual Cycle(MOSBY-ELSEVIER, 2013) Celik, Oner; Celik, Aygen; Atespare, Altay; Boyaci, Zerrin; Celebi, Saban; Gunduz, Tonguc; Aksungar, Fehime Benli; Yelken, KursAtBackground. The reproductive system in females undergoes a regular cyclic change known as the menstrual cycle. Laryngeal changes are evident and fluctuate systematically during the reproductive years with the menstrual cycle. The impact of estrogens in concert with progesterone produces the characteristics of the female voice, with a fundamental frequency (F-0) higher than that of male. Objective. To characterize changes in voice and speech in adolescent females in different phases of the menstrual cycle-during menstruation, after menstruation, mid-menstrual cycle, and premenstruation. Materials and Methods. Sixteen adult females who were nonusers of oral contraceptives participated in a cross-sectional study of menstrual cycle influences on voicing and speaking tasks. Acoustic analysis (F-0, intensity, perturbation measurements [jitter and shimmer], and harmonic-to-noise ratio), maximum phonation time (MPT), s/z ratio, and perceptual assessments (grade [G], roughness [R], breathiness [B], asthenia [A], and strain [S] [GRBAS] and Voice Handicap Index-10 [VHI-10]) scales were performed during all phases. Results. None of the acoustic analysis parameters and MPT and s/z ratio measurements revealed statistically significant difference (P > 0.05). Perceptual voice assessment scales either clinician based or patients self-evaluated showed significant differences among phases (P < 0.05). Conclusions. The objective voice analysis methods, such as acoustic analysis, MPT, and s/z ratio, determined no difference; however, the subjective voice analysis methods, such as clinician-based perceptual assessment (GRBAS) and patients self-evaluation (VHI-10) scales, demonstrated significant changes during different phases of menstrual cycle.Yayın Women's Knowledge of Pap Smear Test and Human Papillomavirus Acceptance of HPV Vaccination to Themselves and Their Daughters in an Islamic Society(LIPPINCOTT WILLIAMS & WILKINS, 2010) Ilter, Erdin; Celik, Aygen; Haliloglu, Berna; Unlugedik, Elif; Midi, Ahmet; Gunduz, Tonguc; Ozekici, UmitObjective: Cancer of cervix uteri is the second most common cancer among women, and it has been shown to be caused by human papillomavirus (HPV) infection in more than 99% of cases. We surveyed Muslim Turkish women, who mostly accept talking about sex as a taboo, to examine their knowledge about Papanicolaou (Pap) smear test, HPV, HPV vaccine, and their attitude toward vaccination to themselves and their daughters. Methods: We surveyed 525 women aged between 19 and 53 years to examine their knowledge about cervical cancer screening Pap smear test, HPV, HPV vaccine, and their attitude toward vaccination to themselves and their daughters with a questionnaire that is consisted of 5 parts with a total of 31 items. Results: The knowledge of cervical screening was high (70%), and 51% of the subjects were at least once had a Pap smear test, but most respondents (56%) had never heard of HPV. For most women, recommendations from health workers (67%) were the major influences in deciding to get vaccinated. Conclusions: The importance of successful introduction on the vaccine by the drug providers and health care professionals in Turkey was shown in this present study with a high rate of awareness of cervical cancer vaccine. "Early-age vaccination knowledge" before any sexual contact is probably due to the correct education of mothers by health care professionals. The professionals should be educated and trained about HPV, vaccination, and its relation with cervical cancer to increase the knowledge about it.
