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Klozapine bağlı siiyalorenin etyolojisi ve tedavisi
(AVES, 2007) Eraslan, Defne; Öztürk, Özgür; Genç, Yasin; Kalyoncu, Ayhan
The side effects of clozapine which is a prominent pharmacotherapeutic choice in resistant schizophrenia causes important disadvantages. Although one third of patients on clozapine treatment suffers from sialorrhoea, it is generally underevaluated. This underevaluation causes the treatment choices to be limited . The aim of this article is to attract the attention on the subject via discussing the etiology and treatment of clozapine induced sialorrhoea. All articles related with clozapine induced sialorrhoea in PUBMED between 1996-2006 were reviewed. ‹t is not certainly known whether sialorrhoea induced by clozapine is caused by impaired balance in muscarinic receptors and ?2 receptor blockade or impairment of swallowing reflex by clozapine. Except from recovering swallowing reflex or lowering clozapine dose, anticholinergic agents such as amitriptyiline, biperiden, ipratropium bromide, ?2 agonists such as clonidine and injection of botilinum toxin might be of benefit in the treatment of clozapine induced sialorrhoea. None of the pharmacologic agents were found superior to each other in the treatment of clozapine induced sialorrhoea. However, it is of great importance to make the best treatment choice of sialorrhoea and inform the patient about non-pharmacological prevention methods in order to increase the quality of life and drug compliance.