Yazar "Gökdemir, Yasemin" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Yayın
    Changing clinical characteristics of non-cystic fibrosis bronchiectasis in children
    (BMC, 2020) Eralp, Ela Erdem; Gökdemir, Yasemin; Etag, Emine; İkizoğlu, Nilay Baş; Ergenekon, Pınar; Yegit, Cansu Yılmaz; Kurt, Arif; Ersu, Refika; Karakoç, Fazilet; Karadağ, Bülent
    Background The prevalence of non-cystic fibrosis (CF) bronchiectasis is increasing in both developed and developing countries in recent years. Although the main features remain similar, etiologies seem to change. Our aim was to evaluate the clinical and laboratory characteristics of our recent non-CF bronchiectasis patients and to compare these with our historical cohort in 2001. Methods One hundred four children with non-CF bronchiectasis followed between 2002 and 2019 were enrolled. Age of diagnosis, underlying etiology and microorganisms in sputum culture were recorded. Clinical outcomes were evaluated in terms of lung function tests and annual pulmonary exacerbation rates at presentation and within the last 12 months. Results Mean FEV1 and FVC %predicted at presentation improved compared to historical cohort (76.6 +/- 17.1 vs. 63.3 +/- 22.1 and 76.6 +/- 15.1 vs. 67.3 +/- 23.1, respectively;p < 0.001). There was a significant decrease in pulmonary exacerbation rate from 6.05 +/- 2.88 at presentation to 3.23 +/- 2.08 during follow-up (p < 0.0001). In 80.8% of patients, an underlying etiology was identified. There was an increase in primary ciliary dyskinesia (PCD) (32.7% vs. 6.3%;p = 0.001), decrease in idiopathic cases (19.2% vs. 37.8%;p = 0.03) with no change in postinfectious and immunodeficiencies as underlying etiology. Sputum cultures were positive in 77.9% of patients which was 46.9% in the historical cohort (p = 0.001). Conclusion Baseline pulmonary function tests were better and distribution of underlying etiology had changed with a remarkable increase in diagnosis of PCD in the recent cohort.
  • Küçük Resim Yok
    Yayın
    Comparison of conventional chest physiotherapy and oscillatory positive expiratory pressure therapy in primary ciliary dyskinesia
    (PubMed, 2020) Bingöl, İbrahim; Gökdemir, Yasemin; Yılmaz Yegit, Cansu; Ergenekon, Pınar; Atağ, Emine; Baş İkizoğlu, Nilay; Erdem Eralp, Ela; Gencer, Kardelen; K Saygı, Evrim; Karakoç, Fazilet; Ersu, Refika; Karadağ, Bülent
    Background: Chest physiotherapy (CP) is a recommended treatment modality in primary ciliary dyskinesia (PCD). Objective: Primary aim was to compare the efficacy and safety of the conventional chest physiotherapy (CCP) and oscillatory positive expiratory pressure therapy (OPEPT). Secondary aims were to compare the exacerbation rate, time until the first exacerbation, patient compliance and comfort between the two CP methods. Methods: This is a 6 month randomized, controlled crossover trial. Patients >6 years of age with PCD were randomized into two groups, first group was assigned to OPEPT (Acapella®) for 3 months while second group was assigned to CCP. Groups were crossed over to the other modality after a 15-day washout period. Pulmonary function tests (PFTs) and compliance were monitored by monthly clinic visits. Results: There was a significant increase in FEV1 , FEF25-75 , and PEF values (p = .018, p = .020, and p = .016, respectively) in the OPEPT group and in FVC values (p = .007) in CCP group compared to baseline. However PFT increase at 3rd month was not superior to each other with both physiotherapy methods. Median acute pulmonary exacerbation rate and time period until the first exacerbation were similar in both groups (p = .821, p = .092, respectively). Comfort and effectiveness of OPEPT was higher than CCP according to patients (p = .029 and p = .042, respectively). There were no adverse effects with either therapy. Conclusions: OPEPT was as effective as CCP in PCD patients. OPEPT was more comfortable and effective than CCP according to patients. OPEPT might be an efficient alternative method for airway cleareance in PCD patients.