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    Effects of spirulina on cyclophosphamide-induced ovarian toxicity in rats: Biochemical and histomorphometric evaluation of the ovary
    (2013) Yener N.A.; Sinanoglu O.; Ilter E.; Celik A.; Sezgin G.; Midi A.; Deveci, Uğur; Aksungar F.; Deveci, Uğur
    Cyclophosphamide (Cyc) is known to cause ovotoxicity and infertility in women. Our aim is to investigate the possible ovotoxic effects of Cyc and possible antioxidant and protective effects of blue-green algae, Spirulina (Sp), in rat ovaries. Eighteen rats were given: group I (n = 6, control); group II (n = 6, CP), a single dose Cyc; group III (n = 6, Sp+Cyc), 7 days Sp+single dose Cyc. Tissue malondialdehyde (MDA) levels, superoxide dismutase (SOD), and catalase (CAT) activities are assessed biochemically. Normal and atretic primordial and primary follicle counts for all sections obtained for each ovary are calculated. Mean number of follicle counts for each group are compared. In Sp+Cyc group, tissue MDA levels were significantly lower than those in the CP and higher than those in the C group (CP > Sp + Cyc > C). Tissue SOD activity was significantly higher in Sp+Cyc group than that in the CP group and lower than that in the C group (C > Sp + Cyc > C). No statistically significant difference was found between the ovarian CAT activities in any group. Histomorphometrically, there was also no significant difference between the mean numbers of normal and atretic small follicle counts. Our results suggest that single dose Cyc has adverse effects on oxidant status of the ovaries and Sp has protective effects in Cyc-induced ovotoxicity. © 2013 Nese Arzu Yener et al.
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    Evaluation of ultrasound-guided transversalis fascia plane block for postoperative analgesia in cesarean section: A prospective, randomized, controlled clinical trial
    (Elsevier Inc., 2020) Serifsoy T.E.; Tulgar S.; Selvi O.; Senturk O.; Ilter E.; Peker B.H.; Ozer Z.
    Study objective: Cesarean Delivery (CD) is a commonly performed obstetric procedure. Adding a regional anesthesia technique to multimodal analgesia in CD, may improve the quality of postoperative analgesia. In this study we evaluated the efficacy of Transversalis Fascia Plane Block (TFPB) for postoperative analgesia management in CD. Design: Blinded, prospective, randomized study. Setting: Postoperative recovery room & ward, tertiary university hospital, Istanbul, Turkey, Patients: Seventy-five patients (ASA II-III) scheduled to undergo Cesarean delivery were recruited. Following exclusion, 70 patients were randomized into two equal groups (block and control group). Interventions: Standard multimodal analgesia (routine paracetamol and tramadol PCA in addition to diclophenac sodium as rescue analgesia) was performed in Group C while TFPB block was also performed in the intervention (TFPB) group. Measurements: The primary outcome was tramadol consumption within the first 24 h. The secondary outcome was Numeric Rating Scale (NRS) scores during rest and movement/coughing. Main results: Tramadol consumption in the first 24 h was 175 ± 72.32 mg in the control and 101.42 ± 51.45 mg in the TFPB group (p < 0.05). NRS was lower in Group TFPB during the first 3 h and at the 12th hour. There was no difference in NRS scores at other hours. Conclusion: Bilateral ultrasound guided TFPB leads to effective analgesia and a decrease in analgesia requirement in first 24 h in patients undergoing CD. © 2019 Elsevier Inc.
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    Gossypiboma: A lesson to learn: Case report
    (2010) Ilter E.; Manukyan, Manuk Norayık; Haliloglu B.; Çelik A.; Özden S.
    The term "gossypiboma" denotes foreign bodies retained after surgery. The most common gossypiboma is the iatrogenic surgical sponge. Usually, hysterectomy, appendectomy and cholecystectomy operations are associated with these retained sponges. They may be misdiagnosed as incisional endometriosis. We present a patient who had a caesarean section operation eleven years ago with a mass at the abdominal wall between the umbilicus and the caesarean section scar on the left paramedian region approximately 5 x 2 cm in diameter. We must keep in mind that prevention is more important for cure. As we knew that most reported cases occur in the presence of a normal pack count, we think that the surgical team must be very careful in the operation room.
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    Turkish experience for the effects of raloxifene hydrochloride on endometrium and mammographic breast density in postmenopausal women with low bone mineral density
    (2005) Karalok H.; Ilter E.; Tufekci E.C.; Batur O.
    Background: To assess the changes in the endometrial tissue and breast density in postmenopausal osteopenic and osteoporotic women after usage of raloxifene for 18 months. Material/Method: We studied the changes in parameters like endometrial thickness and mammographic breast density due to raloxifene in 354 postmenopausal patents with low bone mineral density applied to our hospital's menopause polyclinic. 234 subjects were assigned to the raloxifene group, 120 to the control group. 22 (9.4%) of 234 subjects in the raloxifene group and 15 (12.5%) of 120 subjects in control group left the study during the 18-month treatment period. Results: Although the baseline endometrial thickness values were similar in both groups, there was a small reduction in the thickness in the raloxifene group at the 18th month. There was no change in breast density in the raloxifene group, whereas in the control group breast density increased in many subjects. Although hot flashes were seen frequently more in the raloxifene group, all other adverse events were similar in both groups. Conclusion: Daily therapy with 60mg raloxifene does not stimulate the endometrium and does not influence breast density.