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    The efficacy of donepezil in two cases with alcohol induced Korsakoff's Syndrome [Alkole bagli oluşan "Korsakoff Sendromlu" i·ki olguda donepezil'in etkinligi]
    (2008) Binbay Z.; Mirsal H.; Kalyoncu Ö.A.; Pektaş Ö.; Genç Y.; Ünsalan N.; Beyazyürek M.
    According to DSM-IV, amnestic disorder, known as "Alcohol Induced Persisting Amnestic Disorder" and classically known as "Wernicke Encephalopathy" or "Korsakoff's Syndrome" is an important clinical condition because of the poor nutrition most commonly associated with chronic alcohol abuse. Donepezil, a primarily peripheric and central acetyl cholinesterase inhibitor, increases acetylcholine concentration in cholinergic synapses and can improve symptoms of amnesia. In this article, we present two cases with "Alcohol Induced Persisting Amnestic Disorder" and depressive disorder treated by donepezil, who have shown improvement in cognitive functions. The patients were followed up with the Hamilton Depression Rating Scale (HDRS), and Mini Mental State Examination (MMSE) and clinical observation. In both of the cases, donepezil was added to the antidepressant drug treatment and improvement in cognitive function was noted together with improvement in depressive symptoms. In the first case standard MMSE score increased by 18 points to 26; in the second case by 16 points to 28. Large-scale prospective, double-blind, placebo controlled studies are needed to confirm the efficacy of donepezil in Alcohol Induced Persisting Amnestic Disorder.