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    Combination of oral vancomycin and intra-colonic vancomycin: Successful treatment of complicated pseudomembranous colitis in a child patient
    (SAGE PUBLICATIONS INC, 2019) Bozkurt, Huseyin Sancar; Kara, Banu
    The Clostridium difficile infection-related disease varies from mild diarrhoea to pseudomembranouscolitis. Although C. difficile infection is commonly considered to be a hospital-acquired infection, a significant number of cases are community acquired. Community-acquired C. difficile infection can exhibit itself as ileus or toxic megacolon. Severe C. difficile infection that is unresponsive to intravenous metronidazole therapy requires more aggressive medical management and even surgical intervention. We present our case results for which vancomycin was administered both orally and intra-colonically. With this method, we treated the community acquired C. difficile infection patient who was presented as ileus.
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    A new treatment for ulcerative colitis: Intracolonic Bifidobacterium and xyloglucan application
    (SageJournals, 2020) Bozkurt, Hüseyin Sancar; Kara, Banu
    Ulcerative colitis (UC) pathogenesis includes the altered gut microbiota, environmental factors, and human immune and genetic predisposition. Recently, its association with reduced bifidobacteria quantity in the microbiota is reported. Xyloglucan, a plant-based prebiotic oligosaccharide, causes increase in bifidobacteria quantity. In this article, we share the results of our UC cases treated by intracolonic single-dose administration ofBifidobacterium animalissubsp.lactisand xyloglucan combination. Intracolonic single-dose administration of 200 billion colony-forming units (CFUs) ofB. animalissubsp.lactisand 4 g of xyloglucan combination was administrated to 10 severe UC patients, who were either unresponsive or had inadequate response to treatment. All patients continued treatment after the procedure. Treatment responses were evaluated by colonoscopic, laboratory, and clinical examination after 6 weeks. Intracolonic single-dose administration ofB. animalissubsp.lactisand xyloglucan was found effective in the mucosal healing and resolution of colonic symptoms in UC patients. Intracolonic administration ofB. animalissubsp.lactisand xyloglucan in UC is a new single-strain and strain-specific prebiotic combination method. It is easy to apply and has no observable side effect. Its effectiveness on mucosal healing could be attributed to the enhancement of non-stimulatory status and biodiversity in colonic mucosa. Nonetheless, it is still necessary to develop diagnostic strategies to determine the patients to whom this method would be the most applicable.