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    Is hemithyroidectomy a rational management for benign nodular goitre?
    (VAN ZUIDEN COMMUNICATIONS, 2015) Attaallah, W.; Erel, S.; Canturk, N. Z.; Erbil, Y.; Gorgulu, S.; Kulacoglu, H.; Kocdor, M. A.; Kebudi, A.; Ozbas, S.; Gulluoglu, B. M.
    Background: The incidence and potential risk factors for the recurrence of benign nodular goitre after unilateral thyroidectomy are not clearly defined. The aim of this study was to assess the rate of progression of nodular goitre in the contralateral thyroid lobe and of hypothyroidism requiring replacement therapy after unilateral thyroid lobectomy for benign nodular goitre. Patients and Methods: Patients who underwent hemithyroidectomy for benign nodular goitre between 2000 and 2009 were included in the study. The primary outcome of this study was the reoperation rate for recurrent goitre, the rate of progression of nodular goitre and the rate of hypothyroidism requiring L-T4 replacement therapy. Clinical factors that have an effect on progression were further analysed. Results: 259 patients were included for study. Progression of the nodular goitre in the remnant lobe was observed in 32% (n = 83) of the patients. However, over time, only 2% of these 83 patients underwent contralateral hemithyroidectomy due to this progression. Fifty-six (22%) patients required L-thyroxin replacement due to persistent hypothyroidism after hemithyroidectomy. The factors shown to affect progression of nodular goitre were advanced age, preoperative hyperthyroidism, preoperative diagnosis of toxic nodular goitre and the presence of surgical indication for a toxic goitre causing hyperthyroidism and a definitive pathological diagnosis of nodular hyperplasia. Conclusion: There was a progression of the nodular goitre in the remnant lobe in about one-third of the patients who underwent hemithyroidectomy. However, only 2% of these patients underwent complementary contralateral hemithyroidectomy due to clinical progression in 31 months of follow-up.
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    LYMPHEDEMA AFTER MODIFIED RADICAL MASTECTOMY FOR THE BREAST CANCER: INCIDENCE AND RISK FACTORS
    (Aves, 2005) Kebudi, A.; Uludag, M.; Yetkin, G.; Citgez, B.; Isgor, A.
    BACKGROUND: Lymphedema of the upper limb following breast cancer treatment has severe psycological and physical morbidity. The objective of the current study is to estimate the incidence and the risk factors of arm lymphedema in patients with invasive breast cancer treated with modified radical mastectomy. METHODS: The features of the cases treated with modified radical mastectomy (MRM) between 1999-2003 in our clinic were evaluated in this retrospective study. The effects of the T stage of the primary tumor, axillary nodal invasion, the tumor's stage, radiotherapy and age on the occurence of lymphedema were evaluated. RESULTS: ln that period (mean follow-up time: 40.8+14.8 months (12-72)), 93 female patients (mean age 49.9+13.7) were treated with MRM. Radiotherapy was performed to 44 (% 47.3) patients. Arm lymphedema occured in 7 patients (% 7.5). The earliest lymphedema of the arm occured in postoperative 6. month in 2 cases and after 1. year in postoperative period in 5 cases; the mean occurence time of the lymphedema was 24.8+16.5 (6-44) months. ln the evaluation, lymphedema was detected in 6/ 44 (% 12.6) patients who had radiotherapy. Radiotherapy was detected as the only significant risk factor for the development of the arm lymphedema (p< 0.05). The other factors were nonsignificant. CONCLUSIONS: Radiotheraphy is a predominant risk factor for lymphedema of the arm in patients performed MRM for breast cancer. The prolonged regular followup of the patients for the possible arm lymphedema development is considerable for the early diagnosis and conservative precautions that would be performed instantly.
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    PINEALOBLASTOMAS
    (WILEY-BLACKWELL, 2014) Kebudi, R.; Koc, B.; Agaoglu, F. Yaman; Gorgun, O.; Wolff, J.; Kapu, S. Bay; Kebudi, A.; Darendeliler, E.
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    Second Malignancies in Childhood Cancer Survivors
    (WILEY-BLACKWELL, 2016) Kebudi, R.; Gorgun, O.; Ayan, I.; Agaoglu, F. Yaman; Kebudi, A.; Zulfikar, B.; Buyukkapu, S. Bay; Ozdemir, G. N.; Darendliler, E.
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