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    Clinical-pathogenetic characteristics of joint damage in patients with autoimmune tiroiditis
    (Maltepe Üniversitesi, 2018) Isaac, Boateng; Lyudmila, Pasiyeshvili
    Introduction: The prevalence of autoimmune thyroiditis among the world population is 3-4%, while the frequency of clinically expressed forms of the disease ranges from 1 to 2%. This pathology is diagnosed 8-10 times more often among women. One of the frequent pathologies in autoimmune thyroiditis is joint damage. It can be either an independent disease (rheumatoid arthritis, osteoarthritis) or leakage in the form of arthropathy, resulting from a deficiency of thyroid hormones in the formation of hypothyroidism. The aim of the work is to establish the prevalence of joint damage in patients with autoimmune thyroiditis and to determine the clinical and pathogenetic mechanisms of their course. Methodology: We examined 42 women aged 27 to 49 years with autoimmune thyroiditis with hypothyroidism of moderate severity; 29 patients had subcompensated and 13 women had compensated stage of the disease. The duration of the anamnesis for thyroid diseases ranged from 3 to 19 years. The joint syndrome was assessed with the recommendations of OMERACT III. The number of affected joints, the severity of the pain syndrome according to the Visual Analogue Scale, the Ricci index, the X-ray study and the determination serum concentrations of C-reactive protein and interleukin-1 were determined. The comparison group was represented by 20 patients with autoimmune thyroiditis and hypothyroidism without joint damage. Results: Joint syndrome was observed in 31 patients (73.8%) with autoimmune thyroiditis, 10 (32.2%) of them had hypothyroid arthropathy, 2 (6.5%) had rheumatoid arthritis and in 19 cases (61.3%) osteoarthritis was recorded. The conducted determination of the C-reactive protein content showed that in the comparison group this indicator was 3-3.5 times higher than normal, with arthropathy 5 times, with osteoarthritis more than 7 times. The similar changes were characteristic of the interleukin-1 content. Thus, changes in the indices of C-reactive protein and interleukin-1 had a dependence on the severity of destructive changes in the joint syndrome. Thus, joint damage in patients with autoimmune thyroiditis and hypothyroidism can occur in the form of arthropathy or osteoarthritis, which may be the result of inadequate production of thyroid hormones.
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    Clinical-pathogenetic characteristics of joint damage in patients with autoimmune tiroiditis
    (Maltepe Üniversitesi, 2018) Isaac, Boateng; Lyudmila, Pasiyeshvili; Çakıl, Yaprak Dönmez; Öztopcu, Aslı; Öztürk, Şenay; Özünal, Zeynep Güneş
    The prevalence of autoimmune thyroiditis among the world population is 3-4%, while the frequency of clinically expressed forms of the disease ranges from 1 to 2%. This pathology is diagnosed 8-10 times more often among women. One of the frequent pathologies in auto- immune thyroiditis is joint damage. lt can be either an independent disease (rheumatoid arthritis, osteoarthritis) or leakage in the form of arthropathy, resuIting from a deficiency fl thyroid hormones in the formation of hypothyroidism.