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    Breast cancer in association with thyroid disorders
    (Biomedcentral, 2003) Narin, Y.; Demirbaş, S.; Önde, M.E.; Sayan, Ö.; Kandemir, E.G.; Yaylacı, M.; Öztürk, A.
    Breast cancer is a hormone-dependent neoplasm. Conflicting results regarding the clinical correlation between breast cancer and thyroid diseases have been reported in the literature. Many studies showed that thyroid diseases are common among women with breast cancer [1–6], whereas other reports did not confirm such an association of breast cancer with thyroid diseases [7–11]. Almost every form of thyroid disease, including nodular hyperplasia [12], hyperthyroidism [13] and thyroid cancer [14, 15], has been identified in association with breast cancer. These findings have led to the investigation of the relationship between breast cancer and autoimmune thyroid diseases (AITDs). Such a relationship is not a new observation, and some authors have reported a higher prevalance of AITDs among breast cancer patients than in age-matched control individuals [16–18]. The precise significance of this association remains elusive, and some reports have shown that the presence of thyroid peroxidase (TPO) antibodies is associated with a significant improvement in outcome among breast cancer patients [19] and is of similar importance to other prognostic indices such as axillary nodal status and tumour size [20]. The aim of the present prospective study was to determine the prevalence of thyroid diseases in patients with breast cancer as compared with that in the general female population.
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    Diagnostic value of ischaemia-modified albumin for predicting myocardial ischaemia during myocardial perfusion scintigraphy
    (Sage Journals, 2008) Özmen, Namık; Canbolat, N.; Aparcı, Mustafa; Kardeşoğlu, Ejder; Narin, Y.; Gültepe, M.; Cebeci, Bekir Sıtkı; Dinçtürk, Mehmet
    During acute ischaemia the N-terminal site of albumin is altered, reducing its binding capacity; the modified protein is termed ischaemia-modified albumin (IMA). IMA is a sensitive marker of acute myocardial ischaemia but its diagnostic value in chronic angina pectoris patients is unclear. We investigated changes in blood levels of IMA during myocardial perfusion scintigraphy in patients with chronic angina pectoris in a study including 26 male and 20 female patients, with mean age 60 years. Technetium 99m perfusion imaging detected myocardial ischaemia in 26 patients. Coronary angiography was carried out in these 26 ischaemic patients. Mean IMA values at rest and peak exercise were significantly higher in the ischaemic than the non-ischaemic group. All IMA values were considered negative for cardiac ischaemia. Peak exercise IMA was significantly lower than the pre-exercise level only in the non-ischaemic group. IMA measurements during myocardial perfusion scintigraphy are not helpful in the diagnosis of myocardial ischaemia in patients with stable angina pectoris.
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    Hyperammonemic encephalopathy in a patient with primary hepatic neuroendocrine carcinoma.
    (Springer Link, 2009) Başekim, C.; Haholu, A.; Karagöz, B.; Bilgi, O.; Özgün, A.; Küçükardalı, Y.; Narin, Y.; Yazgan, Y.; Kandemir, E. G.
    A 53-year-old male patient was admitted to our hospital with abdominal pain in the right upper quadrant. There was no change in laboratory investigations other than a slight increase in serum levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), and gamma glutamyl transferase (GGT). Computed tomography (CT) of the abdomen showed multiple hepatic nodular lesions in the liver. Tru-cut biopsy of the lesions was reported as well-differentiated neuroendocrine carcinoma. The patient received sandostatin treatment. After a few days, the patient was hospitalized in the intensive care unit with disturbance of consciousness and clinical features suggestive of encephalopathy. Serum ammonia level was found highly elevated. After the treatment with L-ornithine-L-aspartate, a remarkable improvement in the level of patient's sensorium occurred as well as a reduction in serum ammonia level within a few days. Transarterial chemoembolization (TACE) was performed one week later. The patient's condition began to worsen along with increase in serum ammonia level and he died because of hyperammonemic encephalopathy. There are case reports of hyperammonemia with some malignancies such as multiple myeloma, plasma cell leukemia, and leiomyosarcoma, or in some patients who have received chemotherapy. This case may suggest an association between hyperammonemia and neuroendocrine tumors.