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    Acute kidney injury in Turkey: epidemiological characteristics, etiology, clinical course and prognosis
    (BioMed Central Ltd, 2022) Gürsu, Meltem; Yeğenağa, Itır; Tuğlular, Serhan; Dursun, Belda; Bek, Sibel Gökçay; Bardak, Simge; Onan, Engin; Demir, Serap; Derici, Ülver; Doğukan, Ayhan; Sevinç, Mustafa; Koçyiğit, İsmail; Altun, Eda; Haras, Ali Burak; Altıparmak, Mehmet Rıza; Tombul, Zeki
    Background: In this study, we aimed to evaluate the etiology, comorbidities and outcome of acute kidney injury (AKI) in our country, and if there is, to demonstrate any potential differences in different geographical parts of the country. Methods: This prospective observational study was carried on by Acute Kidney Injury Working Group of Turkish Society of Nephrology. Demographical and clinical data of AKI patients at the time of diagnosis, at the 1 st week and 1 st , 3 rd and 6 th months were evaluated to determine patient and renal survival, and factors associated with prognosis. Results: 776 patients were included (54.7% male, median age: 67 years). Prerenal causes were more frequent, namely dehydration, heart failure and sepsis. 58.9% of patients had at least one renal etiology, most frequently nephrotoxic agent exposure. Etiologic factors were mostly similar through the country. 33.6% of patients needed renal replacement therapy. At the 6 th month of diagnosis, 29.5% of patients had complete, 34.1% had partial recovery, end stage kidney disease ensued in 9.5% and 24.1% died. Death rate was higher in patients from Eastern Anatolian region, those in intensive care unit, patients with prerenal, renal and postrenal etiologies together, stage-3 AKI, sepsis, cirrhosis, heart failure, malignancy, need for renal replacement therapy and those without chronic kidney disease. Conclusion: Physicians dealing with AKI should be alert against dehydration, heart failure and sepsis, nephrotoxic agent exposure while taking care of these patients. Being aware of the characteristics of AKI patients and outcomes in their country would help to prevent AKI and treating better.
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    Acute kidney injury in Turkey: epidemiological characteristics, etiology, clinical course, and prognosis
    (BMC Nephrology, 2022) Gürsu, Meltem; Yeğenağa, Itır; Tuğlular, Serhan; Dursun, Belda; Bek, Sibel Gökçay; Bardak, Simge; Onan, Engin; Demir, Serap; Derici, Ülver; Doğukan, Ayhan; Sevinç, Mustafa; Koçyiğit, İsmail; Altun, Eda; Haras, Ali Burak; Altıparmak, Mehmet Rıza; Tonbul, Halil Zeki
    Background: This study aimed to evaluate the etiologies, comorbidities, and outcomes of acute kidney injury (AKI) in Turkey and determine any potential diferences among diferent geographical parts of the country. Methods: This prospective observational study was conducted by the Acute Kidney Injury Working Group of the Turkish Society of Nephrology. Demographical and clinical data of patients with AKI at the time of diagnosis and at the 1st week and 1st, 3rd, and 6th months of diagnosis were evaluated to determine patient and renal survival and factors associated with patient prognosis. Results: A total of 776 patients were included (54.7% male, median age: 67 years). Prerenal etiologies, including dehydration, heart failure, and sepsis, were more frequent than other etiologies. 58.9% of the patients had at least one renal etiology, with nephrotoxic agent exposure as the most common etiology. The etiologic factors were mostly similar throughout the country. 33.6% of the patients needed kidney replacement therapy. At the 6th month of diagnosis, 29.5% of the patients had complete recovery; 34.1% had partial recovery; 9.5% developed end-stage kidney disease; and 24.1% died. The mortality rate was higher in the patients from the Eastern Anatolian region; those admitted to the intensive care unit; those with prerenal, renal, and postrenal etiologies together, stage 3 AKI, sepsis, cirrhosis, heart failure, and malignancy; those who need kidney replacement therapy; and those without chronic kidney disease than in the other patients. Conclusion: Physicians managing patients with AKI should be alert against dehydration, heart failure, sepsis, and nephrotoxic agent exposure. Understanding the characteristics and outcomes of patients with AKI in their countries would help prevent AKI and improve treatment strategies.