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    Efficiency of prp-therapy in the treatment of venous and diabetic trophic ulcers
    (Maltepe Üniversitesi, 2019) Kharchenko, T.; Melekhovets, O.; Melekhovets, Yu.; Radko, A.; Chumachenko, Ia.
    Introduction: About 18% patients with chronic varicose veins are accompanied by the appearance of trophic ulcers, among patients with diabetes mellitus, this indicator is about 4-10% of patients. The presence of a trophic defect greatly affects the quality of life of patients and, without adequate treatment, leads to disability. The aim of the study is to assess effectiveness of the venous and diabetic trophic ulcers treatment with use of plasmatherapy (PRP). Materials and Methods: Total of 48 persons with trophic ulcers were divided into two groups: 1st group - 24 patients with chronic varicose veins class C6 according to CEAP classification, 2nd group - 24 patients with diabetes mellitus type 2, moderate severity, compensatory stage, diabetic foot syndrome II st. by E. Wagner. Patients were matched according to age, sex, and average duration of wound’s defect (8 mo), average wound area of 6.4 cm2. Before inclusion in the study patients had a specific etiopathogenetic treatment, up to complete wound purification, confirming on the results of bacteriological analysis. The course of PRP-therapy was started for the trophic ulcer on reparation phase. The regiment was consisted of 3 procedures of intradermal injections 1 time per week. For evaluation of the wound healing dynamics, electron application LesionMeter was used at the baseline and 4 weeks after starting treatment. Results: After PRP-therapy a positive effect was observed in 100% of patients. In the 1st group 91.7% (22 patients) achieved complete epithelization and connective tissue scar formation after 4 procedures; in the 2nd group, this figure was achieved in 58.3% (14 patients). Discussion: The lower rate of complete epithelization in patients in the 2nd group was due to the location of the trophic ulcer on the surface that is most exposed to pressure and trauma during movement (plantar surface of the foot).