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Yayın Acute motor axonal neuropathy: A severe complication of alcohol abuse(2010) Sahin S.; Cinar N.; Sezgin G.; Ayalp S.; Karsidag S.…Yayın Adverse skin reaction caused by dabigatran(Verduci Editore, 2014) Cakmak M.A.; Sahin S.; Cinar N.; Karsidag S.…Yayın Blink reflex recovery in central and peripherally originated movement disorders of the cranio-cervical area: A comparative study(2009) Yaman M.; Sahin S.; Kiziltan M.E.Background: Previous studies have shown that enhancement of blink reflex (BR) excitability exists in various movement disorders, notably those involving the cranio-cervical area. In this study the BR recovery curve of the late component (R2) and R2 area was evaluated to determine what changes occur under different conditions and the significance of these changes. Methods: The recovery curve of the blink reflex (BR) was studied inpatients with hemifacial spasm (HFS), post-facial syndrome (PFS), blepharospasm (BS), segmental cranio-cervical dystonia (SD), cervical dystonia without BS (CD), and healthy control subjects. Following initial comparisons between six groups where the increased excitability observed in BS, SD and CD were assumed to be of central origin and that of HFS and PFS of peripheral origin; two additional groups were established and compared in terms of recovery times. Results: Recovery values of 200, 400, 600, 800, 1000 ms and grades for all groups were significantly different when compared to the control group. The most significant difference observed between the groups was at 200 msn and the smallest at 800 msn interstimuli intervals. The subjects within the group referred to as the 'central origined group' recovered faster than those in the 'peripherally origined group' although no statistical difference was found between the two groups at stimulus interval. Conclusion: Our findings suggest that the excitability changes observed among the groups can be attributed to a number of factors. Although the nature and anatomical substrate of the primary pathology involving the reflex cycle leads - to some extent - to differently enhanced excitability patterns, such differences were not considered statistically significant.Yayın Brain-stem listeriosis: A comparison of SPECT and MRI findings(2006) Sahin S.; Arisoy A.S.; Topkaya A.E.; Karsidag S.Listeria monocytogenes, although uncommon as a cause of illness in the general population, can result in serious illness when it affects pregnant women, neonates, the elderly, and immunocompromised individuals. Typically, it is a food-borne organism. This report describes a case of brain-stem listeriosis in a previously healthy 51-year-old woman. The diagnosis was based on clinical findings, the results of cerebrospinal fluid (CSF) analysis, CSF culture, and magnetic resonance imaging (MRI) findings. MRI demonstrated upper brain stem and cerebellar peduncle involvement. In addition, Tc-99m exametazime (HMPAO)-labeled single photon emission computed tomography (SPECT) of the brain revealed bilateral cerebellar hypoperfusion. Antibiotic therapy resulted in partial clinical recovery after 3 weeks. At the end of 6 months, brainstem findings had nearly resolved. However, although minimal residual findings were observed on MRI at 6 months, bilateral diffuse cerebellar hypoperfusion remained on Tc-99m HMPAO brain SPECT. ©2006 Medscape.Yayın A case of Fahr's disease presenting with anxiety disorder: Magnetic resonance spectroscopy findings(2010) Cubuk R.; Sahin S.; Tasali N.; Cinar N.; Cubuk A.Fahr's disease involves calcification of basal ganglia and dentate nuclei of the cerebellum. Radiologic features of Fahr's disease including computed tomography and magnetic resonance imaging are well described in the present literature. To our knowledge, magnetic resonance spectroscopy findings are not described yet. We report a case Fahr's disease presenting with symptoms of anxiety disorder with detailed radiological survey including single voxel magnetic resonance spectroscopy analysis. © Internet Scientific Publications, LLC., 1996 to 2010.Yayın Cerebral blood flow changes in patients with probable medication-overuse headache(2008) Savrun F.K.; Goksan B.; Savrun M.; Sahin R.; Sahin S.Transcranial Doppler (TCD) is a non-invasive method for measuring blood flow velocity (BFV), and a marker of vessel diameter. In this study, intracranial BFV was investigated, by means of TCD, in patients suffering from probable medication-overuse headache (PMOH). Twenty-three female patients with probable ergotamine-overuse headache (PEOH), 23 female patients with probable analgesic-overuse headache (PAOH), and 15 healthy female controls participated in the study. The mean BFVs of the bilateral middle and anterior cerebral arteries (MCA and ACA) and basilar artery (BA) were measured by TCD. The mean BFVs of the BA and MCA were found to be significantly increased in the PEOH group when compared with those of the PAOH and control groups (p<0.05). No significant differences in BFV of the ACA were observed between any groups (p>0.05). The mean BFV of all the vessels in the PAOH group was found to be lower than that of the control group but no statistical significance was found (p>0.05). Our results show that ergotamine increases BFV via vasoconstriction, especially of the BA and MCA. We also suggest that 5HT1B/1D receptors are mainly localized in the BA and MCA, and that analgesic overuse results in a functional disorder of neuronal receptor and neurovascular reflexes and may cause a reduction of intracerebral vessel tone, leading to vasodilatation.Yayın Is there any relationship between streptococcal infection and multiple sclerosis?(2007) Topkaya A.E.; Sahin S.; Aksungar F.B.; Boru U.T.; Yildiz Z.; Sur H.Background: Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of uncertain etiology. Although the mechanisms of inducting autoimmunity by some of the infectious agents have been investigated, there is not yet enough research on streptococcal infections. Material/Methods: To understand the effect of past group A streptococcal infection on MS, antistreptolysin O (ASO) and antideoxyribonuclease B (ADNase B) were measured in 21 patients with relapsing-remitting MS and 21 healthy blood donors by nephelometric assay. Results: ADNase B levels in the patients with MS were found to be significantly higher than in the controls (p<0.001); however, ASO levels were similar in both groups. Conclusions: These findings indicate that a relationship between multiple sclerosis and streptococcal infections may exist, but to acquire a better understanding of the role of group A streptococci in the pathogenesis of multiple sclerosis, more studies with animal models are necessary. © Med Sci Monit, 2007.Yayın What is the impact of electromagnetic waves on epileptic seizures?(2013) Cinar N.; Sahin S.; Erdinc O.O.BACKGROUND: The effects of electromagnetic waves (EMWs) on humans and their relationship with various disorders have been investigated. We aimed to investigate the effects of exposure to different frequencies of EMWs in various durations in a mouse epilepsy model induced by pentylenetetrazole (PTZ).MATERIAL AND METHODS: A total of 180 4-week-old male mice weighing 25-30 g were used in this study. Each experimental group consisted of 10 mice. They were exposed to 900, 700, 500, 300, and 100 MHz EMWs for 20 hours, 12 hours and 2 hours. Following electromagnetic radiation exposure, 60 mg/kg of PTZ was injected intraperitoneally to all mice. Each control was also injected with PTZ without any exposure to EMW. The latency of initial seizure and most severe seizure onset were compared with controls.RESULTS: The shortest initial seizure latency was noted in the 12-hour group, followed by the 700 MHz. The mean initial seizure latencies in the 2-hour EMW exposed group was significantly shorter compared to that in the 12- and 20-hour groups. There was no significant difference between 12- and 20-hour EMW exposed groups. There was a significant difference between control and 2- and 10-hour EMW exposed groups. No statistically significant differences were noted in mean latencies of the most severe seizure latency, following 20-, 12-, and 2- hour EMW exposed groups and control groups.CONCLUSIONS: Our findings suggest that acute exposure to EMW may facilitate epileptic seizures, which may be independent of EMW exposure time. This information might be important for patients with epilepsy. Further studies are needed.
