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    Plasma therapy in patients with erectile dysfunction associated with corona viruse disease (Covid-19)
    (T.C. Maltepe Üniversitesi, 2022) Pryima, Solomiia; Styranivska, Olena; Thomas, Pınar Buket; Öner, Çağrı; Avcı Alpar, Demet; Erkut, Zeynep
    Erectile dysfunction is an inability to achieve or to maintain erection, which is necessary for sexual intercourse. It is divided into psychogenic, organic and mixed. Organic is the most common form. It can be vascular, neurogenic and endocrine. Vascular organic erectile dysfunction amounts around 80%. Usually atherosclerosis and hypertension are the causes .It is accepted the COVID-19 to be a respiratory disease. However, the latest research revealed that the virus has been damaging genitals. It penetrates anywhere where blood vessels are. Penis is highly vascularized organ of body. Fundamentally, virus disrupts blood circulation. Deficiency of endothelin, common in patients with severe course of the coronavirus disease, makes smooth myocytes of arteries impossible to relax and to start latent phase of erection.According to European Association of Urologists researches , the plasma therapy of penis in combination with phosphodiesterase type 5 inhibitors(PDE5) or intracavernous prostaglandin E1 injections (PGE1) greatly intensify effect of these drugs . We studied development of erectile dysfunction(ED) in association with COVID-19, risk factorsoferectiledysfunctionoccurrence,andalso efficiencyandsafetyofplasmatherapyin 15 sexually active patients aged 35-65 years. Methods included International Index of Erectile Function(IIEF-5) and Penile Doppler Ultrasound. According to IIEF-5, all patients were divided into groups: mild degree ( 8 patients), moderate degree -5, and severe degree -2. The initial results of Penile Doppler Ultrasound in men with erectile dysfunction revealed significantly reduced peak systolic velocity( about twice) and increased peak diastolic velocity. After one month of plasma therapy treatment in combination with basic therapy, the indices of Penile Doppler Ultrasound approached normal values. Moreover, 37% of men noticed prolongation of sexual intercourse. Results: The results give a possibility to say that, surely, virus persists not only into lungs and kidneys, but also in male genitals and is saved there for a long time. The risk factors of the coronaviruse disease(COVID-19) and erectile dysfunction(ED) are similar. Patients,60 y.o. with chronic circulatory disorders are in group of the increased risk. Plasma therapy in combination with basic therapy improves efficiency of treatment and facilitate prolongation sexual intercourse. Plasma therapy in patients with erectile dysfunction on the background of COVID-19 is safe and efficient.