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    Implementation of a User-Friendly, Flexible Expert System for Selecting Optimal Set of Kidney Exchange Combinations of Patients in a Transplantation Center
    (ELSEVIER SCIENCE INC, 2015) Karademirci, O.; Terzioglu, A. S.; Yilmaz, S.; Tombus, O.
    Introduction. For end-stage renal disease patients, kidney transplantation is the only long-term solution. The number of deceased donors is limited. Living kidney donation is subject to strict regulations, limiting possible donors only to the extended family of the patient for preventing the organ trade. There may be incompatibilities between the patients and their related donors, such as ABO blood type incompatibility, positive cross-match, and so on. Methods. Pairwise exchanges between donors and recipients increase both the quality and the quantity of feasible transplantations. The maximum benefit in kidney exchanges could only be yielded by developing a central kidney exchange program supported by a nation wide living donor pool database. In the absence of a central kidney exchange program, each transplantation center arranges the kidney allocations using spreadsheets manually. Selecting best possible combination of exchanges simultaneously is a difficult task when performed manually. It is a proven NP-Hard combinatorial optimization problem. However, using mixed integer programming methods the best combination can be found in seconds. Results. We developed a user-friendly decision support system that can be used in transplantation centers, facilitating their operations. Conclusions. The decision support system can be modified for according to the matching preferences of transplantation centers and it can be used as a simulation tool for analyzing different allocation methods.
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    A Possible System for Optimal Donor Kidney Exchange in Turkey
    (ELSEVIER SCIENCE INC, 2012) Cilaci-Tombus, A.; Tombus, O.; Titiz, I.; Ozkan, L.
    The lack of available deceased donors and the immunological incompatibility between the patients and their voluntary donor candidates make kidney exchange among donor-patient pairs a preferable solution performed locally by many organ transplantation centers in Turkey. However, maximum benefit from kidney exchange can only be achieved when the donor patient pool is maximized using a nationwide kidney exchange program. This work discusses kidney exchange practices worldwide to develop a nationwide exchange program in Turkey and related challenges.