COVID-19 drugs and drug repositioning

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dc.contributor.authorTuranalp, İrem Nida
dc.date.accessioned2024-07-12T21:58:28Z
dc.date.available2024-07-12T21:58:28Z
dc.date.issued2021en_US
dc.departmentMaltepe Üniversitesi, Rektörlüken_US
dc.description.abstractIntroduction: The COVID-19 pandemic is caused by SARS-CoV-2. Drug repositioning is a propitious field in the development and discovery of therapeutic agents that distinguishes new therapeutic options for existing drugs. There are repositioned drugs in COVID-19 treatment. Aim: We aimed to explore repositioned drugs for COVID-19 pharmacotherapy. We further classify the drugs according to ATC-DDD pharmacological category. Materials and Methods: Drugs are retrieved from the NIH guideline and national guideline. NIH and national guidelines are compared for treatment approaches. Result and Discussion: Remdesivir, hydroxychloroquine, lopinavir-ritonavir, favipiravir, tocilizumab and interferon regimens are found to be repurposed in clinical guidelines. Hydroxychloroquine is in P01BA group, lopinavir-ritonavir is in J05AX group, interferons are in L03AB group, and favipiravir is in J05AX group. A recent study obtained 21 preexisting drugs which are effectual at blocking SARS-CoV-2 viral replication. Two of them are already FDA approved which are astemizole and clofazimine. 13 of them have been clinically tested and have proved the e ectiveness against SARS-CoV-2, 4 of them have shown that they work synergistically with remdesivir. Remdesivir and corticosteroids are currently recommended by NIH to the hospitalized patients with COVID-19 for their treatment.en_US
dc.identifier.citationTuranalp, İ.N. (2021). COVID-19 drugs and drug repositioning. International Faculty of Medical Sciences and Nursing(MEDNS) Student Congress, Maltepe Üniversitesi. s. 54-55.en_US
dc.identifier.endpage55en_US
dc.identifier.isbn978-605-2124-39-0
dc.identifier.startpage54en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8810
dc.language.isoenen_US
dc.publisherMaltepe Üniversitesien_US
dc.relation.ispartofInternational Faculty of Medical Sciences and Nursing(MEDNS) Student Congressen_US
dc.relation.publicationcategoryUluslararası Konferans Öğesi - Başka Kurum Yazarıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY08058
dc.subjectDrug repositioningen_US
dc.subjectCOVID-19en_US
dc.subjectPandemicen_US
dc.titleCOVID-19 drugs and drug repositioningen_US
dc.typeConference Object
dspace.entity.typePublication

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