Clinical and morphological aspects of mortality in COVID-19
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Maltepe Ăśniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Ă–zet
The most actual problem today in the world is COVID-19. The epicenter of the lesion remains in the lungs. We analyzed the results of pathological autopsies of persons who died as a result of COVID-19 on the basis of the pathological department (PD) of the Regional Clinical Hospital of Ivano-Frankivsk for April-November 2020. During the study period, 164 pathological autopsies of persons who died as a result of COVID-19 were performed in the pathological department, from which 102 (62.20%) were males and 62 were females (38.80%). The average age of the dead is 64.2 years. The immediate cause of death were: respiratory failure - 128 cases (78.05%), multiple organ failure (MOF) - 28 (17.07%), malignant neoplasms - 4 (2.44%), pulmonary heart failure - 2 cases 1.22%), cerebral insufficiency and acute transmural myocardial infarction–by 1 case (0.61%). The most common comorbidity was coronary heart disease (CHD) - 102 cases (62.20%). Hypertension was found in 48 people (29.27%). Among the metabolic disorders were non-insulin dependent diabetes mellitus (DM), which was detected in 19 people (11.59%), obesity - 17 cases (10.37%), and insulin-dependent diabetes mellitus was detected in 1 case (0.61%). Anemia was found in 11 people (6.71%), chronic obstructive pulmonary disease - in 4 people (2.44%), chronic pancreatitis - 3 (1.83%), chronic cholecystitis - 2 (1.22%), chronic glomerulonephritis - 2 (1.22%) and 1 chronic pyelonephritis (0.61%). Morphological changes in the lungs were characterized by diffuse alveolar damage (DAD). The lung tissue is compacted with areas of atelectasis, drainage hemorrhages and hemorrhagic inractions. Sometimes with thrombi of the branches of the pulmonary arteries. Histological examination revealed interstitial pneumonia, microangiopathy with thrombosis, hyaline membranes and / or hemorrhagic edema. When the disease lasted more than 2 weeks, the organization of fibrin with the development of foci of pneumosclerosis or total abscessive pneumonia was observed. Thus, the main cause of death in COVID-19 is respiratory failure. The high risk of developing multiple organ failure in males aged 20-40 years atracts attention. The most common comorbidity is coronary heart disease, which is more common in males. The morphological picture of diffuse alveolar damage in COVID-19 depends on the age of the disease and is manifested by interstitial pneumonia, microangiopathy, abscessive pneumonia, pneumosclerosis.
Açıklama
Anahtar Kelimeler
Kaynak
International Faculty of Medical Sciences and Nursing(MEDNS) Student Congress
WoS Q DeÄźeri
Scopus Q DeÄźeri
Cilt
Sayı
KĂĽnye
Solomia, P., Vladyslav, S., Vitalii, V. ve Serhii, K. (2021). Clinical and morphological aspects of mortality in COVID-19. International Faculty of Medical Sciences and Nursing(MEDNS) Student Congress, Maltepe Ăśniversitesi. s. 42-43.
