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    Histopathologic examination of the effects of cyclosporin a alone and the combined therapy with prednisolone on lung: an experimental study
    (Cambridge University Press, 2003) Altaner, S.; Güven, A.; Coşkun, O.; Barut, C.; Özen, O. A.
    Cyclosporin-A(CsA) is a very potent immunosuppressive agent which is widely used in transplantations and autoimmune diseases. Recent studies suggest an encouraging clinical effect for low-dose, long-term cyclosporin A treatment in different lung diseases[1,2,3,4,5]. Whether administration of CsA might be useful for lowering the dosage of steroids during the treatment of interstitial pneumonia, asthma and lung injuries[6,7,8] is presently a matter of controversy. Several clinical studies reported that CsA might cause pulmonary complications in transplant recipients [9,10]. The aims of this experimental study were: (i) to examine the effects of CsA on lung at morphologic level and to verify the tolerability of long-term, low-dose treatment with this drug; (ii) to analyze if Cremophor-EL(the vehicle in the intravenous form of CyA) is responsible from the changes; (iii) to investigate if combined therapy with Prednisolone has better morphologic results on lung tissue. Forty-eight female Sprague-Dawley rats were divided into four groups: Group I was control. The other three group had daily intraperitoneal injection of 4mg/kg/day CyA for 2,5 months. Group II had oral, Group III had intravenous form of this drug while Group IV had intravenous form of CsA with 1 mg/kg/day prednisolone. Biopsy specimens from lung were embedded in paraffin and the sections were stained with Hematoxylene & Eosin for microscopic examination.
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    Ultrastructural and histochemical characterization of secretory granules in human lung adenocarcinoma cells
    (Cambridge University Press, 2000) Demiralay, E.; Altaner, S.; Candan, L.; Kutlu, A. K.
    Histochemical methods offer an excellent research tool for the characterization of glycoproteins in the secretory cells, thus contributing to the elucidation of the pathophysiology of different diseases. The different staining characteristics of mucins can be useful in diagnostic histopathology. It has been proposed that the reduction in sulphated glycoproteins and an increase in sialomucins in intestinal mucosa was an indicator of premalignant changes in carcinoma of the bowel. It has subsequently argued that this change may be consequence rather than a precursor of neoplasia. It may still be of some value as a marker of a premalignant change although it is somewhat variable. Previous studies have demonstrated the characterization of glycoproteins in different type of epitheloid cells in normal and pathologic conditions by using histochemical and electron microscopic techniques. However; little information has been available concerning the exact features of secretory granules in both normal and tumoral cells in lung.